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Solvent-Controlled, Site-Selective N-Alkylation Reactions of Azolo-Fused Ring Heterocycles at N1-, N2-, and N3-Positions, Including Pyrazolo[3,4- d]pyrimidines, Purines, [1,2,3]Triazolo[4,5]pyridines, and Related Deaza-Compounds.
Bookser BC, Weinhouse MI, Burns AC, Valiere AN, Valdez LJ, Stanczak P, Na J, Rheingold AL, Moore CE, Dyck B. Bookser BC, et al. Among authors: valdez lj. J Org Chem. 2018 Jun 15;83(12):6334-6353. doi: 10.1021/acs.joc.8b00540. Epub 2018 Jun 6. J Org Chem. 2018. PMID: 29790748
Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
Hudson AR, Roach SL, Higuchi RI, Phillips DP, Bissonnette RP, Lamph WW, Yen J, Li Y, Adams ME, Valdez LJ, Vassar A, Cuervo C, Kallel EA, Gharbaoui CJ, Mais DE, Miner JN, Marschke KB, Rungta D, Negro-Vilar A, Zhi L. Hudson AR, et al. Among authors: valdez lj. J Med Chem. 2007 Sep 20;50(19):4699-709. doi: 10.1021/jm070370z. Epub 2007 Aug 17. J Med Chem. 2007. PMID: 17705362
Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Poon MM, Lorrain KI, Stebbins KJ, Edu GC, Broadhead AR, Lorenzana AO, Paulson BE, Baccei CS, Roppe JR, Schrader TO, Valdez LJ, Xiong Y, Chen AC, Lorrain DS. Poon MM, et al. Among authors: valdez lj. Sci Rep. 2024 May 8;14(1):10573. doi: 10.1038/s41598-024-61369-9. Sci Rep. 2024. PMID: 38719983 Free PMC article.