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Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.
Tapias V, Jainuddin S, Ahuja M, Stack C, Elipenahli C, Vignisse J, Gerges M, Starkova N, Xu H, Starkov AA, Bettendorff L, Hushpulian DM, Smirnova NA, Gazaryan IG, Kaidery NA, Wakade S, Calingasan NY, Thomas B, Gibson GE, Dumont M, Beal MF. Tapias V, et al. Among authors: smirnova na. Hum Mol Genet. 2018 Aug 15;27(16):2874-2892. doi: 10.1093/hmg/ddy201. Hum Mol Genet. 2018. PMID: 29860433 Free PMC article.
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.
Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Kaidery NA, et al. Among authors: smirnova na. Antioxid Redox Signal. 2013 Jan 10;18(2):139-57. doi: 10.1089/ars.2011.4491. Epub 2012 Aug 13. Antioxid Redox Signal. 2013. PMID: 22746536 Free PMC article.
L-ascorbic acid: A true substrate for HIF prolyl hydroxylase?
Osipyants AI, Poloznikov AA, Smirnova NA, Hushpulian DM, Khristichenko AY, Chubar TA, Zakhariants AA, Ahuja M, Gaisina IN, Thomas B, Brown AM, Gazaryan IG, Tishkov VI. Osipyants AI, et al. Among authors: smirnova na. Biochimie. 2018 Apr;147:46-54. doi: 10.1016/j.biochi.2017.12.011. Epub 2017 Dec 28. Biochimie. 2018. PMID: 29289682 Free PMC article.
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.
Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR. Haskew-Layton RE, et al. Among authors: smirnova na. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90. doi: 10.1073/pnas.1003996107. Epub 2010 Sep 20. Proc Natl Acad Sci U S A. 2010. PMID: 20855618 Free PMC article.
94 results