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hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.
Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. Segeritz CP, et al. Among authors: madrigal p. J Hepatol. 2018 Oct;69(4):851-860. doi: 10.1016/j.jhep.2018.05.028. Epub 2018 Jun 5. J Hepatol. 2018. PMID: 29879455 Free PMC article.
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.
Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L. Sampaziotis F, et al. Among authors: madrigal p. Nat Biotechnol. 2015 Aug;33(8):845-852. doi: 10.1038/nbt.3275. Epub 2015 Jul 13. Nat Biotechnol. 2015. PMID: 26167629 Free PMC article.
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L. Sampaziotis F, et al. Among authors: madrigal p. Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3. Nat Med. 2017. PMID: 28671689 Free article.
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency.
Bertero A, Brown S, Madrigal P, Osnato A, Ortmann D, Yiangou L, Kadiwala J, Hubner NC, de Los Mozos IR, Sadée C, Lenaerts AS, Nakanoh S, Grandy R, Farnell E, Ule J, Stunnenberg HG, Mendjan S, Vallier L. Bertero A, et al. Among authors: madrigal p. Nature. 2018 Mar 8;555(7695):256-259. doi: 10.1038/nature25784. Epub 2018 Feb 28. Nature. 2018. PMID: 29489750 Free PMC article.
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression.
Cuomo ASE, Seaton DD, McCarthy DJ, Martinez I, Bonder MJ, Garcia-Bernardo J, Amatya S, Madrigal P, Isaacson A, Buettner F, Knights A, Natarajan KN; HipSci Consortium; Vallier L, Marioni JC, Chhatriwala M, Stegle O. Cuomo ASE, et al. Among authors: madrigal p. Nat Commun. 2020 Feb 10;11(1):810. doi: 10.1038/s41467-020-14457-z. Nat Commun. 2020. PMID: 32041960 Free PMC article.
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program.
El-Khairi R, Olszanowski E, Muraro D, Madrigal P, Tilgner K, Chhatriwala M, Vyas S, Chia CY, Vallier L, Rodríguez-Seguí SA. El-Khairi R, et al. Among authors: madrigal p. Stem Cell Reports. 2021 Sep 14;16(9):2289-2304. doi: 10.1016/j.stemcr.2021.07.018. Epub 2021 Aug 26. Stem Cell Reports. 2021. PMID: 34450036 Free PMC article.
52 results