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Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).
Metzger F, Sajid W, Saenger S, Staudenmaier C, van der Poel C, Sobottka B, Schuler A, Sawitzky M, Poirier R, Tuerck D, Schick E, Schaubmar A, Hesse F, Amrein K, Loetscher H, Lynch GS, Hoeflich A, De Meyts P, Schoenfeld HJ. Metzger F, et al. J Biol Chem. 2011 Jun 3;286(22):19501-10. doi: 10.1074/jbc.M110.172189. Epub 2011 Apr 1. J Biol Chem. 2011. PMID: 21460230 Free PMC article.
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity.
Saenger S, Holtmann B, Nilges MR, Schroeder S, Hoeflich A, Kletzl H, Spooren W, Ostrowitzki S, Hanania T, Sendtner M, Metzger F. Saenger S, et al. Among authors: metzger f. Amyotroph Lateral Scler. 2012 Sep;13(5):418-29. doi: 10.3109/17482968.2012.679944. Epub 2012 Aug 7. Amyotroph Lateral Scler. 2012. PMID: 22871074
PEGylation of lysine residues reduces the pro-migratory activity of IGF-I.
Sivaramakrishnan M, Kashyap AS, Amrein B, Saenger S, Meier S, Staudenmaier C, Upton Z, Metzger F. Sivaramakrishnan M, et al. Among authors: metzger f. Biochim Biophys Acta. 2013 Oct;1830(10):4734-42. doi: 10.1016/j.bbagen.2013.06.012. Epub 2013 Jun 23. Biochim Biophys Acta. 2013. PMID: 23800578 Free article.
Phenotype analysis of male transgenic mice overexpressing mutant IGFBP-2 lacking the Cardin-Weintraub sequence motif: Reduced expression of synaptic markers and myelin basic protein in the brain and a lower degree of anxiety-like behaviour.
Schindler N, Mayer J, Saenger S, Gimsa U, Walz C, Brenmoehl J, Ohde D, Wirthgen E, Tuchscherer A, Russo VC, Frank M, Kirschstein T, Metzger F, Hoeflich A. Schindler N, et al. Among authors: metzger f. Growth Horm IGF Res. 2017 Apr;33:1-8. doi: 10.1016/j.ghir.2016.11.003. Epub 2016 Nov 16. Growth Horm IGF Res. 2017. PMID: 27919008 Free article.
182 results