Cunningham JM - Search Results

1

Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies.

Liu H, Tian Y, Lee K, Krishnan P, Wang MK, Whelan S, Mevers E, Soloveva V, Dedic B, Liu X, Cunningham JM. Liu H, et al. Among authors: cunningham jm. J Med Chem. 2018 Jul 26;61(14):6293-6307. doi: 10.1021/acs.jmedchem.8b00704. Epub 2018 Jul 3. J Med Chem. 2018. PMID: 29920098

2

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection.

Côté M, Misasi J, Ren T, Bruchez A, Lee K, Filone CM, Hensley L, Li Q, Ory D, Chandran K, Cunningham J. Côté M, et al. Nature. 2011 Aug 24;477(7364):344-8. doi: 10.1038/nature10380. Nature. 2011. PMID: 21866101 Free PMC article.

3

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe.

Lee K, Ren T, Côté M, Gholamreza B, Misasi J, Bruchez A, Cunningham J. Lee K, et al. ACS Med Chem Lett. 2013 Feb 14;4(2):239-243. doi: 10.1021/ml300370k. Epub 2012 Dec 19. ACS Med Chem Lett. 2013. PMID: 23526644 Free PMC article.

4

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection.

Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. Chandran K, et al. Among authors: cunningham jm. Science. 2005 Jun 10;308(5728):1643-5. doi: 10.1126/science.1110656. Epub 2005 Apr 14. Science. 2005. PMID: 15831716 Free PMC article.

5

Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1.

Wang MK, Ren T, Liu H, Lim SY, Lee K, Honko A, Zhou H, Dyall J, Hensley L, Gartin AK, Cunningham JM. Wang MK, et al. Among authors: cunningham jm. PLoS Pathog. 2018 Sep 28;14(9):e1007322. doi: 10.1371/journal.ppat.1007322. eCollection 2018 Sep. PLoS Pathog. 2018. PMID: 30265711 Free PMC article.

6

Biochemical Basis for Increased Activity of Ebola Glycoprotein in the 2013-16 Epidemic.

Wang MK, Lim SY, Lee SM, Cunningham JM. Wang MK, et al. Among authors: cunningham jm. Cell Host Microbe. 2017 Mar 8;21(3):367-375. doi: 10.1016/j.chom.2017.02.002. Epub 2017 Feb 23. Cell Host Microbe. 2017. PMID: 28238624 Free PMC article.

7

On-Demand Patient-Specific Phenotype-to-Genotype Ebola Virus Characterization.

Beitzel BF, Radoshitzky SR, Di Paola N, Brannan JM, Kimmel D, Caviness K, Soloveva V, Yu S, Postnikova EN, Finch CL, Liu H, Prugar L, Bakken R, Dye JM, Kugelman JR, Cunningham JM, Sanchez-Lockhart M, Kuhn JH, Palacios G. Beitzel BF, et al. Among authors: cunningham jm. Viruses. 2021 Oct 6;13(10):2010. doi: 10.3390/v13102010. Viruses. 2021. PMID: 34696439 Free PMC article.

8

Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.

Sivakumaren SC, Shim H, Zhang T, Ferguson FM, Lundquist MR, Browne CM, Seo HS, Paddock MN, Manz TD, Jiang B, Hao MF, Krishnan P, Wang DG, Yang TJ, Kwiatkowski NP, Ficarro SB, Cunningham JM, Marto JA, Dhe-Paganon S, Cantley LC, Gray NS. Sivakumaren SC, et al. Among authors: cunningham jm. Cell Chem Biol. 2020 May 21;27(5):525-537.e6. doi: 10.1016/j.chembiol.2020.02.003. Epub 2020 Mar 3. Cell Chem Biol. 2020. PMID: 32130941 Free PMC article.

9

Filoviruses require endosomal cysteine proteases for entry but exhibit distinct protease preferences.

Misasi J, Chandran K, Yang JY, Considine B, Filone CM, Côté M, Sullivan N, Fabozzi G, Hensley L, Cunningham J. Misasi J, et al. J Virol. 2012 Mar;86(6):3284-92. doi: 10.1128/JVI.06346-11. Epub 2012 Jan 11. J Virol. 2012. PMID: 22238307 Free PMC article.

10

Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1.

Chery J, Petri A, Wagschal A, Lim SY, Cunningham J, Vasudevan S, Kauppinen S, Näär AM. Chery J, et al. Nucleic Acid Ther. 2018 Oct;28(5):273-284. doi: 10.1089/nat.2018.0722. Epub 2018 Aug 22. Nucleic Acid Ther. 2018. PMID: 30133337 Free PMC article.

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