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Page 1
POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.
Huang YH, Klingbeil O, He XY, Wu XS, Arun G, Lu B, Somerville TDD, Milazzo JP, Wilkinson JE, Demerdash OE, Spector DL, Egeblad M, Shi J, Vakoc CR. Huang YH, et al. Among authors: demerdash oe. Genes Dev. 2018 Jul 1;32(13-14):915-928. doi: 10.1101/gad.314815.118. Epub 2018 Jun 26. Genes Dev. 2018. PMID: 29945888 Free PMC article.
A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.
Lu B, Klingbeil O, Tarumoto Y, Somerville TDD, Huang YH, Wei Y, Wai DC, Low JKK, Milazzo JP, Wu XS, Cao Z, Yan X, Demerdash OE, Huang G, Mackay JP, Kinney JB, Shi J, Vakoc CR. Lu B, et al. Among authors: demerdash oe. Cancer Cell. 2018 Dec 10;34(6):970-981.e8. doi: 10.1016/j.ccell.2018.10.015. Epub 2018 Nov 29. Cancer Cell. 2018. PMID: 30503706 Free PMC article.
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.
Somerville TD, Biffi G, Daßler-Plenker J, Hur SK, He XY, Vance KE, Miyabayashi K, Xu Y, Maia-Silva D, Klingbeil O, Demerdash OE, Preall JB, Hollingsworth MA, Egeblad M, Tuveson DA, Vakoc CR. Somerville TD, et al. Among authors: demerdash oe. Elife. 2020 Apr 24;9:e53381. doi: 10.7554/eLife.53381. Elife. 2020. PMID: 32329713 Free PMC article.
Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.
Yang Z, Wu XS, Wei Y, Polyanskaya SA, Iyer SV, Jung M, Lach FP, Adelman ER, Klingbeil O, Milazzo JP, Kramer M, Demerdash OE, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Smogorzewska A, Vakoc CR. Yang Z, et al. Among authors: demerdash oe. Cancer Discov. 2021 Sep;11(9):2300-2315. doi: 10.1158/2159-8290.CD-20-1542. Epub 2021 Apr 23. Cancer Discov. 2021. PMID: 33893150 Free PMC article.
SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia.
Wei Y, Huang YH, Skopelitis DS, Iyer SV, Costa ASH, Yang Z, Kramer M, Adelman ER, Klingbeil O, Demerdash OE, Polyanskaya SA, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Vakoc CR. Wei Y, et al. Among authors: demerdash oe. Cancer Discov. 2022 Feb;12(2):450-467. doi: 10.1158/2159-8290.CD-20-1849. Epub 2021 Sep 16. Cancer Discov. 2022. PMID: 34531253 Free PMC article.
A computational algorithm to predict shRNA potency.
Knott SRV, Maceli A, Erard N, Chang K, Marran K, Zhou X, Gordon A, Demerdash OE, Wagenblast E, Kim S, Fellmann C, Hannon GJ. Knott SRV, et al. Among authors: demerdash oe. Mol Cell. 2014 Dec 18;56(6):796-807. doi: 10.1016/j.molcel.2014.10.025. Epub 2014 Nov 26. Mol Cell. 2014. PMID: 25435137 Free PMC article.
PTPN23-dependent ESCRT machinery functions as a cell death checkpoint.
Song D, Cen Y, Qian Z, Wu XS, Rivera K, Wee TL, Demerdash OE, Chang K, Pappin D, Vakoc CR, Tonks NK. Song D, et al. Among authors: demerdash oe. Nat Commun. 2024 Nov 28;15(1):10364. doi: 10.1038/s41467-024-54749-2. Nat Commun. 2024. PMID: 39609437
MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer.
Klingbeil O, Skopelitis D, Tonelli C, Yoshimoto T, Alpsoy A, Panepinto MC, Minicozzi F, Merrill JR, Cafiero AM, Aggarwal D, Russo S, Ha T, Demerdash OE, Wee TL, Spector DL, Lyons SK, Tuveson DA, Cifani P, Vakoc CR. Klingbeil O, et al. Among authors: demerdash oe. Cancer Discov. 2024 Jul 26. doi: 10.1158/2159-8290.CD-23-1529. Online ahead of print. Cancer Discov. 2024. PMID: 39058094