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Page 1
Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
Laurent AP, Siret A, Ignacimouttou C, Panchal K, Diop M, Jenni S, Tsai YC, Roos-Weil D, Aid Z, Prade N, Lagarde S, Plassard D, Pierron G, Daudigeos E, Lecluse Y, Droin N, Bornhauser BC, Cheung LC, Crispino JD, Gaudry M, Bernard OA, Macintyre E, Barin Bonnigal C, Kotecha RS, Geoerger B, Ballerini P, Bourquin JP, Delabesse E, Mercher T, Malinge S. Laurent AP, et al. Clin Cancer Res. 2020 Jul 1;26(13):3307-3318. doi: 10.1158/1078-0432.CCR-19-3519. Epub 2020 Mar 27. Clin Cancer Res. 2020. PMID: 32220889 Free PMC article.
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
Bhansali RS, Rammohan M, Lee P, Laurent AP, Wen Q, Suraneni P, Yip BH, Tsai YC, Jenni S, Bornhauser B, Siret A, Fruit C, Pacheco-Benichou A, Harris E, Besson T, Thompson BJ, Goo YA, Hijiya N, Vilenchik M, Izraeli S, Bourquin JP, Malinge S, Crispino JD. Bhansali RS, et al. Among authors: laurent ap. J Clin Invest. 2021 Jan 4;131(1):e135937. doi: 10.1172/JCI135937. J Clin Invest. 2021. PMID: 33393494 Free PMC article.
A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.
Marques Da Costa ME, Zaidi S, Scoazec JY, Droit R, Lim WC, Marchais A, Salmon J, Cherkaoui S, Morscher RJ, Laurent A, Malinge S, Mercher T, Tabone-Eglinger S, Goddard I, Pflumio F, Calvo J, Redini F, Entz-Werlé N, Soriano A, Villanueva A, Cairo S, Chastagner P, Moro M, Owens C, Casanova M, Hladun-Alvaro R, Berlanga P, Daudigeos-Dubus E, Dessen P, Zitvogel L, Lacroix L, Pierron G, Delattre O, Schleiermacher G, Surdez D, Geoerger B. Marques Da Costa ME, et al. Commun Biol. 2023 Sep 18;6(1):949. doi: 10.1038/s42003-023-05320-0. Commun Biol. 2023. PMID: 37723198 Free PMC article.
Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.
Carey-Smith SL, Simad MH, Panchal K, Aya-Bonilla C, Smolders H, Lin S, Armitage JD, Nguyen VT, Bentley K, Ford J, Singh S, Oommen J, Laurent AP, Mercher T, Crispino JD, Montgomery AP, Kassiou M, Besson T, Deau E, Meijer L, Cheung LC, Kotecha RS, Malinge S. Carey-Smith SL, et al. Among authors: laurent ap. Haematologica. 2024 Jul 1;109(7):2309-2315. doi: 10.3324/haematol.2023.284271. Haematologica. 2024. PMID: 38426275 Free PMC article. No abstract available.
Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia.
Reglero C, Dieck CL, Zask A, Forouhar F, Laurent AP, Lin WW, Albero R, Miller HI, Ma C, Gastier-Foster JM, Loh ML, Tong L, Stockwell BR, Palomero T, Ferrando AA. Reglero C, et al. Among authors: laurent ap. Cancer Discov. 2022 Nov 2;12(11):2646-2665. doi: 10.1158/2159-8290.CD-22-0010. Cancer Discov. 2022. PMID: 35984649 Free PMC article.
Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma.
Cortes JR, Filip I, Albero R, Patiño-Galindo JA, Quinn SA, Lin WW, Laurent AP, Shih BB, Brown JA, Cooke AJ, Mackey A, Einson J, Zairis S, Rivas-Delgado A, Laginestra MA, Pileri S, Campo E, Bhagat G, Ferrando AA, Rabadan R, Palomero T. Cortes JR, et al. Among authors: laurent ap. Cell Rep. 2022 Apr 19;39(3):110695. doi: 10.1016/j.celrep.2022.110695. Cell Rep. 2022. PMID: 35443168 Free PMC article.
Romidepsin and Afatinib Abrogate Jak-Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma.
Shih BB, Ma C, Cortes JR, Reglero C, Miller H, Quinn SA, Albero R, Laurent AP, Mackey A, Ferrando AA, Geskin L, Palomero T. Shih BB, et al. Among authors: laurent ap. J Invest Dermatol. 2024 Jul;144(7):1579-1589.e8. doi: 10.1016/j.jid.2023.12.010. Epub 2024 Jan 14. J Invest Dermatol. 2024. PMID: 38219917 Free article.