Chen S - Search Results

1

Discovery of a drug candidate for GLIS3-associated diabetes.

Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ, Zhu Z, Tomishima M, Liu C, Naji A, Evans T, Huangfu D, Chen S. Amin S, et al. Among authors: chen s. Nat Commun. 2018 Jul 11;9(1):2681. doi: 10.1038/s41467-018-04918-x. Nat Commun. 2018. PMID: 29992946 Free PMC article.

2

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Huangfu D, et al. Among authors: chen s. Nat Biotechnol. 2008 Nov;26(11):1269-75. doi: 10.1038/nbt.1502. Epub 2008 Oct 12. Nat Biotechnol. 2008. PMID: 18849973

3

A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. Chen S, et al. Nat Chem Biol. 2009 Apr;5(4):258-65. doi: 10.1038/nchembio.154. Epub 2009 Mar 15. Nat Chem Biol. 2009. PMID: 19287398

4

Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes.

Kao DI, Chen S. Kao DI, et al. Among authors: chen s. Regen Med. 2012 Jul;7(4):583-93. doi: 10.2217/rme.12.27. Regen Med. 2012. PMID: 22817630 Review.

5

Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling.

Tsai SY, Maass K, Lu J, Fishman GI, Chen S, Evans T. Tsai SY, et al. Among authors: chen s. Stem Cell Reports. 2015 Jun 9;4(6):1089-102. doi: 10.1016/j.stemcr.2015.04.015. Epub 2015 May 28. Stem Cell Reports. 2015. PMID: 26028533 Free PMC article.

6

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. Fattahi F, et al. Among authors: chen s. Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951. Epub 2016 Feb 10. Nature. 2016. PMID: 26863197 Free PMC article.

7

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells.

Simsek S, Zhou T, Robinson CL, Tsai SY, Crespo M, Amin S, Lin X, Hon J, Evans T, Chen S. Simsek S, et al. Among authors: chen s. Stem Cells Transl Med. 2016 May;5(5):572-9. doi: 10.5966/sctm.2015-0276. Epub 2016 Mar 31. Stem Cells Transl Med. 2016. PMID: 27034411 Free PMC article.

8

Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation.

Feng L, Cook B, Tsai SY, Zhou T, LaFlamme B, Evans T, Chen S. Feng L, et al. Among authors: chen s. Cell Rep. 2016 May 31;15(9):2063-75. doi: 10.1016/j.celrep.2016.04.066. Epub 2016 May 19. Cell Rep. 2016. PMID: 27210748 Free PMC article.

9

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery.

Zeng H, Guo M, Zhou T, Tan L, Chong CN, Zhang T, Dong X, Xiang JZ, Yu AS, Yue L, Qi Q, Evans T, Graumann J, Chen S. Zeng H, et al. Among authors: chen s. Cell Stem Cell. 2016 Sep 1;19(3):326-40. doi: 10.1016/j.stem.2016.07.002. Epub 2016 Aug 11. Cell Stem Cell. 2016. PMID: 27524441 Free PMC article.

10

Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells.

Liang H, Zheng QL, Fang P, Zhang J, Zhang T, Liu W, Guo M, Robinson CL, Chen SB, Chen XP, Chen FP, Zeng H. Liang H, et al. Sci Rep. 2017 Jan 18;7:40361. doi: 10.1038/srep40361. Sci Rep. 2017. PMID: 28098170 Free PMC article.

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