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Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.
Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T. Yamaguchi-Kabata Y, et al. Among authors: takeda m. Hum Genet. 2018 Jul;137(6-7):521-533. doi: 10.1007/s00439-018-1906-z. Epub 2018 Jul 13. Hum Genet. 2018. PMID: 30006735 Free PMC article.
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.
Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M. Morihara T, et al. Among authors: takeda m. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2638-43. doi: 10.1073/pnas.1307345111. Epub 2014 Feb 4. Proc Natl Acad Sci U S A. 2014. PMID: 24497505 Free PMC article.
A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.
Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S. Hirano A, et al. Among authors: takeda m. Psychiatr Genet. 2015 Aug;25(4):139-46. doi: 10.1097/YPG.0000000000000090. Psychiatr Genet. 2015. PMID: 26049409
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M. Kimura R, et al. Among authors: takeda m. Hum Mol Genet. 2007 Jan 1;16(1):15-23. doi: 10.1093/hmg/ddl437. Epub 2006 Nov 29. Hum Mol Genet. 2007. PMID: 17135279
KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M. Hayashi N, et al. Among authors: takeda m. Dement Geriatr Cogn Disord. 2010;30(4):302-8. doi: 10.1159/000320482. Epub 2010 Sep 25. Dement Geriatr Cogn Disord. 2010. PMID: 20881395
Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis.
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M. Ohi K, et al. Among authors: takeda m. Am J Med Genet B Neuropsychiatr Genet. 2012 Jun;159B(4):405-13. doi: 10.1002/ajmg.b.32043. Epub 2012 Mar 27. Am J Med Genet B Neuropsychiatr Genet. 2012. PMID: 22461181
4,078 results