Bai L - Search Results

1

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

Zhao Y, Zhou B, Bai L, Liu L, Yang CY, Meagher JL, Stuckey JA, McEachern D, Przybranowski S, Wang M, Ran X, Aguilar A, Hu Y, Kampf JW, Li X, Zhao T, Li S, Wen B, Sun D, Wang S. Zhao Y, et al. Among authors: bai l. J Med Chem. 2018 Jul 26;61(14):6110-6120. doi: 10.1021/acs.jmedchem.8b00483. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 30015487 Free PMC article.

2

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

Sun H, Nikolovska-Coleska Z, Yang CY, Qian D, Lu J, Qiu S, Bai L, Peng Y, Cai Q, Wang S. Sun H, et al. Among authors: bai l. Acc Chem Res. 2008 Oct;41(10):1264-77. doi: 10.1021/ar8000553. Acc Chem Res. 2008. PMID: 18937395 Free PMC article.

3

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. Lu J, et al. Among authors: bai l. Cancer Res. 2008 Nov 15;68(22):9384-93. doi: 10.1158/0008-5472.CAN-08-2655. Cancer Res. 2008. PMID: 19010913 Free PMC article.

4

Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases.

Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Zhang B, et al. Among authors: bai l. J Med Chem. 2008 Dec 11;51(23):7352-5. doi: 10.1021/jm801146d. J Med Chem. 2008. PMID: 19012392 Free PMC article.

5

Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors.

Gomez C, Bai L, Zhang J, Nikolovska-Coleska Z, Chen J, Yi H, Wang S. Gomez C, et al. Among authors: bai l. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1733-6. doi: 10.1016/j.bmcl.2009.01.091. Epub 2009 Jan 31. Bioorg Med Chem Lett. 2009. PMID: 19243938

6

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.

Chen J, Bai L, Bernard D, Nikolovska-Coleska Z, Gomez C, Zhang J, Yi H, Wang S. Chen J, et al. Among authors: bai l. ACS Med Chem Lett. 2010 May 13;1(2):85-89. doi: 10.1021/ml100010j. ACS Med Chem Lett. 2010. PMID: 20596242 Free PMC article.

7

Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases.

Yang J, McEachern D, Li W, Davis MA, Li H, Morgan MA, Bai L, Sebolt JT, Sun H, Lawrence TS, Wang S, Sun Y. Yang J, et al. Among authors: bai l. Mol Cancer Ther. 2011 Apr;10(4):658-69. doi: 10.1158/1535-7163.MCT-10-0643. Epub 2011 Jan 31. Mol Cancer Ther. 2011. PMID: 21282353 Free PMC article.

8

Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment.

Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S. Lu J, et al. Among authors: bai l. Mol Cancer Ther. 2011 May;10(5):902-14. doi: 10.1158/1535-7163.MCT-10-0864. Epub 2011 Mar 3. Mol Cancer Ther. 2011. PMID: 21372226 Free PMC article.

9

Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.

Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Sun H, et al. Among authors: bai l. J Med Chem. 2011 May 12;54(9):3306-18. doi: 10.1021/jm101651b. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21462933 Free PMC article.

10

LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.

Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S. Bai L, et al. Cancer Res. 2012 Mar 1;72(5):1229-38. doi: 10.1158/0008-5472.CAN-11-2428. Epub 2012 Jan 12. Cancer Res. 2012. PMID: 22241084 Free PMC article.

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