Morcos PN - Search Results

1

Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib.

Morcos PN, Cleary Y, Sturm-Pellanda C, Guerini E, Abt M, Donzelli M, Vazvaei F, Balas B, Parrott N, Yu L. Morcos PN, et al. J Clin Pharmacol. 2018 Dec;58(12):1618-1628. doi: 10.1002/jcph.1286. Epub 2018 Jul 27. J Clin Pharmacol. 2018. PMID: 30052269 Free PMC article.

2

Effect of Food and Esomeprazole on the Pharmacokinetics of Alectinib, a Highly Selective ALK Inhibitor, in Healthy Subjects.

Morcos PN, Guerini E, Parrott N, Dall G, Blotner S, Bogman K, Sturm C, Balas B, Martin-Facklam M, Phipps A. Morcos PN, et al. Clin Pharmacol Drug Dev. 2017 Jul;6(4):388-397. doi: 10.1002/cpdd.296. Epub 2016 Sep 28. Clin Pharmacol Drug Dev. 2017. PMID: 27545320 Clinical Trial.

3

Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib.

Morcos PN, Cleary Y, Guerini E, Dall G, Bogman K, De Petris L, Viteri S, Bordogna W, Yu L, Martin-Facklam M, Phipps A. Morcos PN, et al. Clin Pharmacol Drug Dev. 2017 May;6(3):280-291. doi: 10.1002/cpdd.298. Epub 2016 Sep 28. Clin Pharmacol Drug Dev. 2017. PMID: 27545757 Clinical Trial.

4

Effect of the Wetting Agent Sodium Lauryl Sulfate on the Pharmacokinetics of Alectinib: Results From a Bioequivalence Study in Healthy Subjects.

Morcos PN, Parrott N, Banken L, Timpe C, Lindenberg M, Guerini E, Dall G, Bogman K, Sturm C, Zeaiter A, Martin-Facklam M, Phipps A. Morcos PN, et al. Clin Pharmacol Drug Dev. 2017 May;6(3):266-279. doi: 10.1002/cpdd.299. Epub 2016 Oct 3. Clin Pharmacol Drug Dev. 2017. PMID: 27545871 Clinical Trial.

5

Effect of alectinib on cardiac electrophysiology: results from intensive electrocardiogram monitoring from the pivotal phase II NP28761 and NP28673 studies.

Morcos PN, Bogman K, Hubeaux S, Sturm-Pellanda C, Ruf T, Bordogna W, Golding S, Zeaiter A, Abt M, Balas B. Morcos PN, et al. Cancer Chemother Pharmacol. 2017 Mar;79(3):559-568. doi: 10.1007/s00280-017-3253-5. Epub 2017 Feb 27. Cancer Chemother Pharmacol. 2017. PMID: 28243683 Clinical Trial.

6

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development.

Cleary Y, Gertz M, Morcos PN, Yu L, Youdim K, Phipps A, Fowler S, Parrott N. Cleary Y, et al. Among authors: morcos pn. Clin Pharmacol Ther. 2018 Sep;104(3):505-514. doi: 10.1002/cpt.956. Epub 2017 Dec 27. Clin Pharmacol Ther. 2018. PMID: 29226313

7

Exposure-response analysis of alectinib in crizotinib-resistant ALK-positive non-small cell lung cancer.

Morcos PN, Nueesch E, Jaminion F, Guerini E, Hsu JC, Bordogna W, Balas B, Mercier F. Morcos PN, et al. Cancer Chemother Pharmacol. 2018 Jul;82(1):129-138. doi: 10.1007/s00280-018-3597-5. Epub 2018 May 10. Cancer Chemother Pharmacol. 2018. PMID: 29748847 Free PMC article.

8

Pharmacometric analyses of alectinib to facilitate approval of the optimal dose for the first-line treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer.

Hsu JC, Jaminion F, Guerini E, Balas B, Bordogna W, Morcos PN, Frey N. Hsu JC, et al. Among authors: morcos pn. CPT Pharmacometrics Syst Pharmacol. 2021 Nov;10(11):1357-1370. doi: 10.1002/psp4.12702. Epub 2021 Sep 21. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34547184 Free PMC article.

9

Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment.

Heinig K, Miya K, Kamei T, Guerini E, Fraier D, Yu L, Bansal S, Morcos PN. Heinig K, et al. Among authors: morcos pn. Bioanalysis. 2016 Jul;8(14):1465-79. doi: 10.4155/bio-2016-0068. Epub 2016 Jun 22. Bioanalysis. 2016. PMID: 27329641

10

Physiologically Based Absorption Modeling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Alectinib.

Parrott NJ, Yu LJ, Takano R, Nakamura M, Morcos PN. Parrott NJ, et al. Among authors: morcos pn. AAPS J. 2016 Nov;18(6):1464-1474. doi: 10.1208/s12248-016-9957-3. Epub 2016 Jul 22. AAPS J. 2016. PMID: 27450228 Clinical Trial.

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