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Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free "GeneSwitch" vector.
Cheng S, Tereshchenko J, Zimmer V, Vachey G, Pythoud C, Rey M, Liefhebber J, Raina A, Streit F, Mazur A, Bähr M, Konstantinova P, Déglon N, Kügler S. Cheng S, et al. Among authors: rey m. Exp Neurol. 2018 Nov;309:79-90. doi: 10.1016/j.expneurol.2018.07.017. Epub 2018 Aug 1. Exp Neurol. 2018. PMID: 30076831
AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.
Miniarikova J, Zimmer V, Martier R, Brouwers CC, Pythoud C, Richetin K, Rey M, Lubelski J, Evers MM, van Deventer SJ, Petry H, Déglon N, Konstantinova P. Miniarikova J, et al. Among authors: rey m. Gene Ther. 2017 Oct;24(10):630-639. doi: 10.1038/gt.2017.71. Epub 2017 Aug 3. Gene Ther. 2017. PMID: 28771234 Free PMC article.
The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes.
Merienne N, Vachey G, de Longprez L, Meunier C, Zimmer V, Perriard G, Canales M, Mathias A, Herrgott L, Beltraminelli T, Maulet A, Dequesne T, Pythoud C, Rey M, Pellerin L, Brouillet E, Perrier AL, du Pasquier R, Déglon N. Merienne N, et al. Among authors: rey m. Cell Rep. 2017 Sep 19;20(12):2980-2991. doi: 10.1016/j.celrep.2017.08.075. Cell Rep. 2017. PMID: 28930690 Free article.
Maximizing lentiviral vector gene transfer in the CNS.
Humbel M, Ramosaj M, Zimmer V, Regio S, Aeby L, Moser S, Boizot A, Sipion M, Rey M, Déglon N. Humbel M, et al. Among authors: rey m. Gene Ther. 2021 Feb;28(1-2):75-88. doi: 10.1038/s41434-020-0172-6. Epub 2020 Jul 6. Gene Ther. 2021. PMID: 32632267 Free PMC article.
Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.
Blessing D, Vachey G, Pythoud C, Rey M, Padrun V, Wurm FM, Schneider BL, Déglon N. Blessing D, et al. Among authors: rey m. Mol Ther Methods Clin Dev. 2018 Nov 22;13:14-26. doi: 10.1016/j.omtm.2018.11.004. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2018. PMID: 30591923 Free PMC article.
Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.
Cambon K, Zimmer V, Martineau S, Gaillard MC, Jarrige M, Bugi A, Miniarikova J, Rey M, Hassig R, Dufour N, Auregan G, Hantraye P, Perrier AL, Déglon N. Cambon K, et al. Among authors: rey m. Mol Ther Methods Clin Dev. 2017 May 11;5:259-276. doi: 10.1016/j.omtm.2017.05.001. eCollection 2017 Jun 16. Mol Ther Methods Clin Dev. 2017. PMID: 28603746 Free PMC article.
Correction: Maximizing lentiviral vector gene transfer in the CNS.
Humbel M, Ramosaj M, Zimmer V, Regio S, Aeby L, Moser S, Boizot A, Sipion M, Rey M, Déglon N. Humbel M, et al. Among authors: rey m. Gene Ther. 2022 May;29(5):312. doi: 10.1038/s41434-022-00334-5. Gene Ther. 2022. PMID: 35413992 Free PMC article. No abstract available.
Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.
Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Déglon N. Drouet V, et al. Among authors: rey m. PLoS One. 2014 Jun 13;9(6):e99341. doi: 10.1371/journal.pone.0099341. eCollection 2014. PLoS One. 2014. PMID: 24926995 Free PMC article.
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Q Do K, Halliez S, Bezzi P, Buée L, Leuba G, Colin M, Toni N, Déglon N. Richetin K, et al. Among authors: rey m. Nat Neurosci. 2020 Dec;23(12):1567-1579. doi: 10.1038/s41593-020-00728-x. Epub 2020 Nov 9. Nat Neurosci. 2020. PMID: 33169029
1,041 results