Griffiths SC - Search Results

1

Calibration-free In Vitro Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software.

Nolan R, Alvarez LA, Griffiths SC, Elegheert J, Siebold C, Padilla-Parra S. Nolan R, et al. Among authors: griffiths sc. J Vis Exp. 2018 Jul 17;(137):58157. doi: 10.3791/58157. J Vis Exp. 2018. PMID: 30080195 Free PMC article.

2

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.

Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL. Holtz AM, et al. Among authors: griffiths sc. J Cell Biol. 2015 Jun 8;209(5):739-57. doi: 10.1083/jcb.201411024. J Cell Biol. 2015. PMID: 26056142 Free PMC article.

3

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR. Elegheert J, et al. Among authors: griffiths sc. Nat Protoc. 2018 Dec;13(12):2991-3017. doi: 10.1038/s41596-018-0075-9. Nat Protoc. 2018. PMID: 30455477 Free PMC article.

4

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malinauskaite L, Brignani S, van den Munkhof MH, Düdükcü Ö, De Ruiter AA, Van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ, Siebold C. Robinson RA, et al. Among authors: griffiths sc. Cell. 2021 Apr 15;184(8):2103-2120.e31. doi: 10.1016/j.cell.2021.02.045. Epub 2021 Mar 18. Cell. 2021. PMID: 33740419 Free PMC article.

5

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.

Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C. Griffiths SC, et al. Nat Commun. 2021 Dec 9;12(1):7171. doi: 10.1038/s41467-021-27475-2. Nat Commun. 2021. PMID: 34887403 Free PMC article.

6

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling.

Griffiths SC, Tan J, Wagner A, Blazer LL, Adams JJ, Srinivasan S, Moghisaei S, Sidhu SS, Siebold C, Ho HH. Griffiths SC, et al. Elife. 2024 May 23;13:e71980. doi: 10.7554/eLife.71980. Elife. 2024. PMID: 38780011 Free PMC article.

7

Molecular mechanism of BMP signal control by Twisted gastrulation.

Malinauskas T, Moore G, Rudolf AF, Eggington H, Belnoue-Davis HL, El Omari K, Griffiths SC, Woolley RE, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe HL, Siebold C. Malinauskas T, et al. Among authors: griffiths sc. Nat Commun. 2024 Jun 11;15(1):4976. doi: 10.1038/s41467-024-49065-8. Nat Commun. 2024. PMID: 38862520 Free PMC article.

8

Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase.

Griffiths S, Byrne RT, Antson AA, Whelan F. Griffiths S, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):333-6. doi: 10.1107/S1744309112003831. Epub 2012 Feb 22. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22442237 Free PMC article.

9

A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer.

Liu J, Chiang HC, Xiong W, Laurent V, Griffiths SC, Dülfer J, Deng H, Sun X, Yin YW, Li W, Audoly LP, An Z, Schürpf T, Li R, Zhang N. Liu J, et al. Among authors: griffiths sc. J Immunother Cancer. 2023 Jun;11(6):e006720. doi: 10.1136/jitc-2023-006720. J Immunother Cancer. 2023. PMID: 37328286 Free PMC article.

10

Staphylococcal Periscope proteins Aap, SasG, and Pls project noncanonical legume-like lectin adhesin domains from the bacterial surface.

Clark LC, Atkin KE, Whelan F, Brentnall AS, Harris G, Towell AM, Turkenburg JP, Liu Y, Feizi T, Griffiths SC, Geoghegan JA, Potts JR. Clark LC, et al. Among authors: griffiths sc. J Biol Chem. 2023 Mar;299(3):102936. doi: 10.1016/j.jbc.2023.102936. Epub 2023 Jan 24. J Biol Chem. 2023. PMID: 36702253 Free PMC article.

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