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PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.
Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D. Gavin AL, et al. Among authors: de la torre jc. Nat Immunol. 2018 Sep;19(9):942-953. doi: 10.1038/s41590-018-0179-y. Epub 2018 Aug 13. Nat Immunol. 2018. PMID: 30111894 Free PMC article.
Type I interferon is a therapeutic target for virus-induced lethal vascular damage.
Baccala R, Welch MJ, Gonzalez-Quintial R, Walsh KB, Teijaro JR, Nguyen A, Ng CT, Sullivan BM, Zarpellon A, Ruggeri ZM, de la Torre JC, Theofilopoulos AN, Oldstone MB. Baccala R, et al. Among authors: de la torre jc. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30. doi: 10.1073/pnas.1408148111. Epub 2014 Jun 2. Proc Natl Acad Sci U S A. 2014. PMID: 24889626 Free PMC article.
Editorial overview: Viral immunology.
de la Torre JC, Teijaro J. de la Torre JC, et al. Curr Opin Virol. 2019 Feb;34:vii-viii. doi: 10.1016/j.coviro.2019.03.003. Curr Opin Virol. 2019. PMID: 31006423 No abstract available.
406 results