Li RJ - Search Results

1

Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking.

Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Chakravarty H, Zhang S, Tam KY, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS. Lyu J, et al. Among authors: li rj. Int J Biol Sci. 2018 Jun 23;14(10):1175-1185. doi: 10.7150/ijbs.26011. eCollection 2018. Int J Biol Sci. 2018. PMID: 30123067 Free PMC article.

2

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Wang M, Shim JS, Li RJ, Dang Y, He Q, Das M, Liu JO. Wang M, et al. Among authors: li rj. Br J Pharmacol. 2014 Oct;171(19):4478-89. doi: 10.1111/bph.12800. Epub 2014 Sep 5. Br J Pharmacol. 2014. PMID: 24903412 Free PMC article.

3

Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism.

Shim JS, Li RJ, Lv J, Head SA, Yang EJ, Liu JO. Shim JS, et al. Among authors: li rj. Cancer Lett. 2015 Jun 28;362(1):106-15. doi: 10.1016/j.canlet.2015.03.022. Epub 2015 Mar 20. Cancer Lett. 2015. PMID: 25799952 Free PMC article.

4

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.

Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS. Wang G, et al. Among authors: li rj. Elife. 2015 Jul 28;4:e08261. doi: 10.7554/eLife.08261. Elife. 2015. PMID: 26218223 Free PMC article.

5

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO. Head SA, et al. Among authors: li rj. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7276-85. doi: 10.1073/pnas.1512867112. Epub 2015 Dec 10. Proc Natl Acad Sci U S A. 2015. PMID: 26655341 Free PMC article.

6

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

Shim JS, Li RJ, Bumpus NN, Head SA, Kumar Pasunooti K, Yang EJ, Lv J, Shi W, Liu JO. Shim JS, et al. Among authors: li rj. Clin Cancer Res. 2016 Jun 1;22(11):2709-20. doi: 10.1158/1078-0432.CCR-15-1888. Epub 2016 Jan 22. Clin Cancer Res. 2016. PMID: 26801248

7

Regulation of mTORC1 by lysosomal calcium and calmodulin.

Li RJ, Xu J, Fu C, Zhang J, Zheng YG, Jia H, Liu JO. Li RJ, et al. Elife. 2016 Oct 27;5:e19360. doi: 10.7554/eLife.19360. Elife. 2016. PMID: 27787197 Free PMC article.

8

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim JS, Liu JO. Head SA, et al. Among authors: li rj. ACS Chem Biol. 2017 Jan 20;12(1):174-182. doi: 10.1021/acschembio.6b00849. Epub 2016 Dec 2. ACS Chem Biol. 2017. PMID: 28103683 Free PMC article.

9

Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth.

Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Yang C, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS. Lyu J, et al. Among authors: li rj. Cancer Lett. 2017 Nov 28;409:91-103. doi: 10.1016/j.canlet.2017.09.009. Epub 2017 Sep 18. Cancer Lett. 2017. PMID: 28923401 Free PMC article.

10

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition.

Li Y, Pasunooti KK, Li RJ, Liu W, Head SA, Shi WQ, Liu JO. Li Y, et al. Among authors: li rj. J Med Chem. 2018 Dec 27;61(24):11158-11168. doi: 10.1021/acs.jmedchem.8b01252. Epub 2018 Dec 10. J Med Chem. 2018. PMID: 30481027

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