Orr ME - Search Results

1

Tau protein aggregation is associated with cellular senescence in the brain.

Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME. Musi N, et al. Among authors: orr me. Aging Cell. 2018 Dec;17(6):e12840. doi: 10.1111/acel.12840. Epub 2018 Oct 11. Aging Cell. 2018. PMID: 30126037 Free PMC article.

2

Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.

Medina DX, Orr ME, Oddo S. Medina DX, et al. Among authors: orr me. Neurobiol Aging. 2014 Jan;35(1):79-87. doi: 10.1016/j.neurobiolaging.2013.07.006. Epub 2013 Aug 15. Neurobiol Aging. 2014. PMID: 23954172

3

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.

Orr ME, Salinas A, Buffenstein R, Oddo S. Orr ME, et al. Neurobiol Aging. 2014 Jun;35(6):1233-42. doi: 10.1016/j.neurobiolaging.2013.12.006. Epub 2013 Dec 14. Neurobiol Aging. 2014. PMID: 24411482 Free PMC article.

4

Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.

Orr ME, Garbarino VR, Salinas A, Buffenstein R. Orr ME, et al. Neurobiol Aging. 2015 Mar;36(3):1496-504. doi: 10.1016/j.neurobiolaging.2014.12.004. Epub 2014 Dec 12. Neurobiol Aging. 2015. PMID: 25576082 Free PMC article.

5

Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes.

Liang H, Nie J, Van Skike CE, Valentine JM, Orr ME. Liang H, et al. Among authors: orr me. Adv Exp Med Biol. 2019;1128:185-225. doi: 10.1007/978-981-13-3540-2_10. Adv Exp Med Biol. 2019. PMID: 31062331 Review.

6

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system.

Ramirez P, Zuniga G, Sun W, Beckmann A, Ochoa E, DeVos SL, Hyman B, Chiu G, Roy ER, Cao W, Orr M, Buggia-Prevot V, Ray WJ, Frost B. Ramirez P, et al. Prog Neurobiol. 2022 Jan;208:102181. doi: 10.1016/j.pneurobio.2021.102181. Epub 2021 Oct 17. Prog Neurobiol. 2022. PMID: 34670118 Free PMC article.

7

A geroscience motivated approach to treat Alzheimer's disease: Senolytics move to clinical trials.

Gonzales MM, Krishnamurthy S, Garbarino V, Daeihagh AS, Gillispie GJ, Deep G, Craft S, Orr ME. Gonzales MM, et al. Among authors: orr me. Mech Ageing Dev. 2021 Dec;200:111589. doi: 10.1016/j.mad.2021.111589. Epub 2021 Oct 21. Mech Ageing Dev. 2021. PMID: 34687726 Free PMC article. Review.

8

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes.

Xu P, Wang M, Song WM, Wang Q, Yuan GC, Sudmant PH, Zare H, Tu Z, Orr ME, Zhang B. Xu P, et al. Among authors: orr me. Mol Neurodegener. 2022 Jan 9;17(1):5. doi: 10.1186/s13024-021-00507-7. Mol Neurodegener. 2022. PMID: 35000600 Free PMC article.

9

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.

Gonzales MM, Garbarino VR, Marques Zilli E, Petersen RC, Kirkland JL, Tchkonia T, Musi N, Seshadri S, Craft S, Orr ME. Gonzales MM, et al. Among authors: orr me. J Prev Alzheimers Dis. 2022;9(1):22-29. doi: 10.14283/jpad.2021.62. J Prev Alzheimers Dis. 2022. PMID: 35098970 Free PMC article. Clinical Trial.

10

Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.

Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME. Dehkordi SK, et al. Among authors: orr tc, orr me. Nat Aging. 2021 Dec;1(12):1107-1116. doi: 10.1038/s43587-021-00142-3. Epub 2021 Dec 10. Nat Aging. 2021. PMID: 35531351 Free PMC article.

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