Lourenco C - Search Results

1

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.

Dingar D, Tu WB, Resetca D, Lourenco C, Tamachi A, De Melo J, Houlahan KE, Kalkat M, Chan PK, Boutros PC, Raught B, Penn LZ. Dingar D, et al. Among authors: lourenco c. Nat Commun. 2018 Aug 29;9(1):3502. doi: 10.1038/s41467-018-05660-0. Nat Commun. 2018. PMID: 30158517 Free PMC article.

2

Myc and its interactors take shape.

Tu WB, Helander S, Pilstål R, Hickman KA, Lourenco C, Jurisica I, Raught B, Wallner B, Sunnerhagen M, Penn LZ. Tu WB, et al. Among authors: lourenco c. Biochim Biophys Acta. 2015 May;1849(5):469-83. doi: 10.1016/j.bbagrm.2014.06.002. Epub 2014 Jun 14. Biochim Biophys Acta. 2015. PMID: 24933113 Review.

3

MYC Deregulation in Primary Human Cancers.

Kalkat M, De Melo J, Hickman KA, Lourenco C, Redel C, Resetca D, Tamachi A, Tu WB, Penn LZ. Kalkat M, et al. Among authors: lourenco c. Genes (Basel). 2017 May 25;8(6):151. doi: 10.3390/genes8060151. Genes (Basel). 2017. PMID: 28587062 Free PMC article. Review.

4

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth.

Lustig LC, Dingar D, Tu WB, Lourenco C, Kalkat M, Inamoto I, Ponzielli R, Chan WCW, Shin JA, Penn LZ. Lustig LC, et al. Among authors: lourenco c. Oncogene. 2017 Dec 7;36(49):6830-6837. doi: 10.1038/onc.2017.275. Epub 2017 Aug 14. Oncogene. 2017. PMID: 28806396

5

Lysine-52 stabilizes the MYC oncoprotein through an SCF^Fbxw7-independent mechanism.

De Melo J, Kim SS, Lourenco C, Penn LZ. De Melo J, et al. Among authors: lourenco c. Oncogene. 2017 Dec 7;36(49):6815-6822. doi: 10.1038/onc.2017.268. Epub 2017 Aug 14. Oncogene. 2017. PMID: 28806398

6

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ. Tu WB, et al. Among authors: lourenco c. Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001. Cancer Cell. 2018. PMID: 30300580 Free article.

7

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZ. Kalkat M, et al. Among authors: lourenco c. Mol Cell. 2018 Dec 6;72(5):836-848.e7. doi: 10.1016/j.molcel.2018.09.031. Epub 2018 Nov 8. Mol Cell. 2018. PMID: 30415952 Free article.

8

Modelling the MYC-driven normal-to-tumour switch in breast cancer.

Lourenco C, Kalkat M, Houlahan KE, De Melo J, Longo J, Done SJ, Boutros PC, Penn LZ. Lourenco C, et al. Dis Model Mech. 2019 Jul 26;12(7):dmm038083. doi: 10.1242/dmm.038083. Dis Model Mech. 2019. PMID: 31350286 Free PMC article.

9

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.

Mergenthaler P, Hariharan S, Pemberton JM, Lourenco C, Penn LZ, Andrews DW. Mergenthaler P, et al. Among authors: lourenco c. PLoS Comput Biol. 2021 Feb 22;17(2):e1008630. doi: 10.1371/journal.pcbi.1008630. eCollection 2021 Feb. PLoS Comput Biol. 2021. PMID: 33617523 Free PMC article.

10

MYC protein interactors in gene transcription and cancer.

Lourenco C, Resetca D, Redel C, Lin P, MacDonald AS, Ciaccio R, Kenney TMG, Wei Y, Andrews DW, Sunnerhagen M, Arrowsmith CH, Raught B, Penn LZ. Lourenco C, et al. Nat Rev Cancer. 2021 Sep;21(9):579-591. doi: 10.1038/s41568-021-00367-9. Epub 2021 Jun 29. Nat Rev Cancer. 2021. PMID: 34188192 Review.

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