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Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.
Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE. Kurnik M, et al. Among authors: pedersen js. Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197194 Free article.
A SAXS study of glucagon fibrillation.
Oliveira CL, Behrens MA, Pedersen JS, Erlacher K, Otzen D, Pedersen JS. Oliveira CL, et al. Among authors: pedersen js. J Mol Biol. 2009 Mar 20;387(1):147-61. doi: 10.1016/j.jmb.2009.01.020. J Mol Biol. 2009. PMID: 19385046
Mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques: TFE-induced unfolding of KcsA in DDM surfactant.
Calcutta A, Jessen CM, Behrens MA, Oliveira CL, Renart ML, González-Ros JM, Otzen DE, Pedersen JS, Malmendal A, Nielsen NC. Calcutta A, et al. Among authors: pedersen js. Biochim Biophys Acta. 2012 Sep;1818(9):2290-301. doi: 10.1016/j.bbamem.2012.04.005. Epub 2012 Apr 14. Biochim Biophys Acta. 2012. PMID: 22525601 Free article.
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
Lorenzen N, Nielsen SB, Buell AK, Kaspersen JD, Arosio P, Vad BS, Paslawski W, Christiansen G, Valnickova-Hansen Z, Andreasen M, Enghild JJ, Pedersen JS, Dobson CM, Knowles TP, Otzen DE. Lorenzen N, et al. Among authors: pedersen js. J Am Chem Soc. 2014 Mar 12;136(10):3859-68. doi: 10.1021/ja411577t. Epub 2014 Feb 28. J Am Chem Soc. 2014. PMID: 24527756
How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro.
Lorenzen N, Nielsen SB, Yoshimura Y, Vad BS, Andersen CB, Betzer C, Kaspersen JD, Christiansen G, Pedersen JS, Jensen PH, Mulder FA, Otzen DE. Lorenzen N, et al. Among authors: pedersen js. J Biol Chem. 2014 Aug 1;289(31):21299-310. doi: 10.1074/jbc.M114.554667. Epub 2014 Jun 6. J Biol Chem. 2014. PMID: 24907278 Free PMC article.
474 results