Beal KM - Search Results

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Evolution of a comprehensive, orthogonal approach to sequence variant analysis for biotherapeutics.

Lin TJ, Beal KM, Brown PW, DeGruttola HS, Ly M, Wang W, Chu CH, Dufield RL, Casperson GF, Carroll JA, Friese OV, Figueroa B Jr, Marzilli LA, Anderson K, Rouse JC. Lin TJ, et al. Among authors: beal km. MAbs. 2019 Jan;11(1):1-12. doi: 10.1080/19420862.2018.1531965. Epub 2018 Oct 25. MAbs. 2019. PMID: 30303443 Free PMC article. Review.

Utilization of sequence variants as biomarkers to analyze population dynamics in cloned cell lines.

Lin TJ, Beal KM, DeGruttola HS, Brennan S, Marzilli LA, Anderson K. Lin TJ, et al. Among authors: beal km. Biotechnol Bioeng. 2017 Aug;114(8):1744-1752. doi: 10.1002/bit.26298. Epub 2017 May 18. Biotechnol Bioeng. 2017. PMID: 28369783

Analytical subcloning of a clonal cell line demonstrates cellular heterogeneity that does not impact process consistency or robustness.

Scarcelli JJ, Hone M, Beal K, Ortega A, Figueroa B, Starkey JA, Anderson K. Scarcelli JJ, et al. Biotechnol Prog. 2018 May;34(3):602-612. doi: 10.1002/btpr.2646. Epub 2018 Jul 1. Biotechnol Prog. 2018. PMID: 29693321 Free PMC article.

The impact of expression vector position on transgene transcription allows for rational expression vector design in a targeted integration system.

Beal KM, Bandara KR, Ali SR, Sonak RG, Barnes MR, Scarcelli JJ, Zhang L. Beal KM, et al. Biotechnol J. 2023 Sep;18(9):e2300038. doi: 10.1002/biot.202300038. Epub 2023 Jun 9. Biotechnol J. 2023. PMID: 37272404

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