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Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies.
Hu-Lowe DD, Chen E, Zhang L, Watson KD, Mancuso P, Lappin P, Wickman G, Chen JH, Wang J, Jiang X, Amundson K, Simon R, Erbersdobler A, Bergqvist S, Feng Z, Swanson TA, Simmons BH, Lippincott J, Casperson GF, Levin WJ, Stampino CG, Shalinsky DR, Ferrara KW, Fiedler W, Bertolini F. Hu-Lowe DD, et al. Among authors: casperson gf. Cancer Res. 2011 Feb 15;71(4):1362-73. doi: 10.1158/0008-5472.CAN-10-1451. Epub 2011 Jan 6. Cancer Res. 2011. PMID: 21212415 Free PMC article.
PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity.
Zhang CC, Yan Z, Zhang Q, Kuszpit K, Zasadny K, Qiu M, Painter CL, Wong A, Kraynov E, Arango ME, Mehta PP, Popoff I, Casperson GF, Los G, Bender S, Anderes K, Christensen JG, VanArsdale T. Zhang CC, et al. Among authors: casperson gf. Clin Cancer Res. 2010 Nov 1;16(21):5177-88. doi: 10.1158/1078-0432.CCR-10-1343. Epub 2010 Sep 9. Clin Cancer Res. 2010. PMID: 20829331
Human monoclonal antibodies to the insulin-like growth factor 1 receptor inhibit receptor activation and tumor growth in preclinical studies.
Runnels HA, Arbuckle JA, Bailey KS, Nicastro PJ, Sun D, Pegg JA, Meyer DM, Evans M, Bono CP, Lie WR, Moffat MA, Casperson GF, Lennard S, Elvin J, Vaughan T, Smith CE, Morton PA. Runnels HA, et al. Among authors: casperson gf. Adv Ther. 2010 Jul;27(7):458-75. doi: 10.1007/s12325-010-0026-5. Epub 2010 Jun 14. Adv Ther. 2010. PMID: 20574692
A peptide isolated by phage display binds to ICAM-1 and inhibits binding to LFA-1.
Welply JK, Steininger CN, Caparon M, Michener ML, Howard SC, Pegg LE, Meyer DM, De Ciechi PA, Devine CS, Casperson GF. Welply JK, et al. Among authors: casperson gf. Proteins. 1996 Nov;26(3):262-70. doi: 10.1002/(SICI)1097-0134(199611)26:3<262::AID-PROT3>3.0.CO;2-G. Proteins. 1996. PMID: 8953648
22 results