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Page 1
Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody.
Zhang H, Zhu X, Pascual G, Wadia JS, Keogh E, Hoozemans JJ, Siregar B, Inganäs H, Stoop EJM, Goudsmit J, Apetri A, Koudstaal W, Wilson IA. Zhang H, et al. Among authors: pascual g. Structure. 2018 Dec 4;26(12):1626-1634.e4. doi: 10.1016/j.str.2018.08.012. Epub 2018 Oct 11. Structure. 2018. PMID: 30318466 Free article.
Immunological memory to hyperphosphorylated tau in asymptomatic individuals.
Pascual G, Wadia JS, Zhu X, Keogh E, Kükrer B, van Ameijde J, Inganäs H, Siregar B, Perdok G, Diefenbach O, Nahar T, Sprengers I, Koldijk MH, der Linden EC, Peferoen LA, Zhang H, Yu W, Li X, Wagner M, Moreno V, Kim J, Costa M, West K, Fulton Z, Chammas L, Luckashenak N, Fletcher L, Holland T, Arnold C, Anthony Williamson R, Hoozemans JJ, Apetri A, Bard F, Wilson IA, Koudstaal W, Goudsmit J. Pascual G, et al. Acta Neuropathol. 2017 May;133(5):767-783. doi: 10.1007/s00401-017-1705-y. Epub 2017 Mar 24. Acta Neuropathol. 2017. PMID: 28341999 Free PMC article.
A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, Zhang H, Keogh E, Holland T, Wadia J, Verveen H, Siregar B, Mrosek M, Taggenbrock R, Ameijde J, Inganäs H, van Winsen M, Koldijk MH, Zuijdgeest D, Borgers M, Dockx K, Stoop EJM, Yu W, Brinkman-van der Linden EC, Ummenthum K, van Kolen K, Mercken M, Steinbacher S, de Marco D, Hoozemans JJ, Wilson IA, Koudstaal W, Goudsmit J. Apetri A, et al. Among authors: pascual g. Acta Neuropathol Commun. 2018 May 31;6(1):43. doi: 10.1186/s40478-018-0543-z. Acta Neuropathol Commun. 2018. PMID: 29855358 Free PMC article.
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.
van Ameijde J, Crespo R, Janson R, Juraszek J, Siregar B, Verveen H, Sprengers I, Nahar T, Hoozemans JJ, Steinbacher S, Willems R, Delbroek L, Borgers M, Dockx K, Van Kolen K, Mercken M, Pascual G, Koudstaal W, Apetri A. van Ameijde J, et al. Among authors: pascual g. Acta Neuropathol Commun. 2018 Jul 12;6(1):59. doi: 10.1186/s40478-018-0562-9. Acta Neuropathol Commun. 2018. PMID: 30001207 Free PMC article.
Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
Jones HG, Ritschel T, Pascual G, Brakenhoff JPJ, Keogh E, Furmanova-Hollenstein P, Lanckacker E, Wadia JS, Gilman MSA, Williamson RA, Roymans D, van 't Wout AB, Langedijk JP, McLellan JS. Jones HG, et al. Among authors: pascual g. PLoS Pathog. 2018 Mar 6;14(3):e1006935. doi: 10.1371/journal.ppat.1006935. eCollection 2018 Mar. PLoS Pathog. 2018. PMID: 29509814 Free PMC article.
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.
Li X, Koudstaal W, Fletcher L, Costa M, van Winsen M, Siregar B, Inganäs H, Kim J, Keogh E, Macedo J, Holland T, Perry S, Bard F, Hoozemans JJ, Goudsmit J, Apetri A, Pascual G. Li X, et al. Among authors: pascual g. Acta Neuropathol. 2019 May;137(5):825-836. doi: 10.1007/s00401-019-01974-5. Epub 2019 Feb 25. Acta Neuropathol. 2019. PMID: 30805666 Free PMC article.
Transient opening of trimeric prefusion RSV F proteins.
Gilman MSA, Furmanova-Hollenstein P, Pascual G, B van 't Wout A, Langedijk JPM, McLellan JS. Gilman MSA, et al. Among authors: pascual g. Nat Commun. 2019 May 8;10(1):2105. doi: 10.1038/s41467-019-09807-5. Nat Commun. 2019. PMID: 31068578 Free PMC article.
201 results