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The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.
Thapa D, Wu K, Stoner MW, Xie B, Zhang M, Manning JR, Lu Z, Li JH, Chen Y, Gucek M, Playford MP, Mehta NN, Harmon D, O'Doherty RM, Jurczak MJ, Sack MN, Scott I. Thapa D, et al. Among authors: harmon d. J Biol Chem. 2018 Nov 16;293(46):17676-17684. doi: 10.1074/jbc.AC118.005462. Epub 2018 Oct 15. J Biol Chem. 2018. PMID: 30323061 Free PMC article.
Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.
Costa DK, Huckestein BR, Edmunds LR, Petersen MC, Nasiri A, Butrico GM, Abulizi A, Harmon DB, Lu C, Mantell BS, Hartman DJ, Camporez JP, O'Doherty RM, Cline GW, Shulman GI, Jurczak MJ. Costa DK, et al. Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E105-16. doi: 10.1152/ajpendo.00042.2016. Epub 2016 May 10. Am J Physiol Endocrinol Metab. 2016. PMID: 27166280 Free PMC article.
Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
Harmon DB, Mandler WK, Sipula IJ, Dedousis N, Lewis SE, Eckels JT, Du J, Wang Y, Huckestein BR, Pagano PJ, Cifuentes-Pagano E, Homanics GE, Van't Erve TJ, Stefanovic-Racic M, Jurczak MJ, O'Doherty RM, Kelley EE. Harmon DB, et al. Diabetes. 2019 Jun;68(6):1221-1229. doi: 10.2337/db18-1198. Epub 2019 Apr 1. Diabetes. 2019. PMID: 30936145 Free PMC article.
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. Harmon DB, et al. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):682-91. doi: 10.1161/ATVBAHA.116.307166. Epub 2016 Feb 11. Arterioscler Thromb Vasc Biol. 2016. PMID: 26868208 Free PMC article.
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion.
Cutchins A, Harmon DB, Kirby JL, Doran AC, Oldham SN, Skaflen M, Klibanov AL, Meller N, Keller SR, Garmey J, McNamara CA. Cutchins A, et al. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):317-24. doi: 10.1161/ATVBAHA.111.234856. Epub 2011 Nov 10. Arterioscler Thromb Vasc Biol. 2012. PMID: 22075252 Free PMC article.
B2 cells suppress experimental abdominal aortic aneurysms.
Meher AK, Johnston WF, Lu G, Pope NH, Bhamidipati CM, Harmon DB, Su G, Zhao Y, McNamara CA, Upchurch GR Jr, Ailawadi G. Meher AK, et al. Am J Pathol. 2014 Nov;184(11):3130-41. doi: 10.1016/j.ajpath.2014.07.006. Epub 2014 Sep 3. Am J Pathol. 2014. PMID: 25194661 Free PMC article.
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