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A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
Vidimar V, Licona C, Cerón-Camacho R, Guerin E, Coliat P, Venkatasamy A, Ali M, Guenot D, Le Lagadec R, Jung AC, Freund JN, Pfeffer M, Mellitzer G, Sava G, Gaiddon C. Vidimar V, et al. Among authors: mellitzer g. Cancer Lett. 2019 Jan;440-441:145-155. doi: 10.1016/j.canlet.2018.09.029. Epub 2018 Oct 17. Cancer Lett. 2019. PMID: 30339780
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.
Vidimar V, Meng X, Klajner M, Licona C, Fetzer L, Harlepp S, Hébraud P, Sidhoum M, Sirlin C, Loeffler JP, Mellitzer G, Sava G, Pfeffer M, Gaiddon C. Vidimar V, et al. Among authors: mellitzer g. Biochem Pharmacol. 2012 Dec 1;84(11):1428-36. doi: 10.1016/j.bcp.2012.08.022. Epub 2012 Sep 1. Biochem Pharmacol. 2012. PMID: 22964219
A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.
Licona C, Spaety ME, Capuozzo A, Ali M, Santamaria R, Armant O, Delalande F, Van Dorsselaer A, Cianferani S, Spencer J, Pfeffer M, Mellitzer G, Gaiddon C. Licona C, et al. Among authors: mellitzer g. Oncotarget. 2017 Jan 10;8(2):2568-2584. doi: 10.18632/oncotarget.13711. Oncotarget. 2017. PMID: 27935863 Free PMC article.
45 results