Dowling DP - Search Results

1

Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity.

Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V, Drennan CL. Grell TAJ, et al. Among authors: dowling dp. Protein Sci. 2019 Jan;28(1):202-215. doi: 10.1002/pro.3529. Protein Sci. 2019. PMID: 30341796 Free PMC article.

2

Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 chemistry.

Dowling DP, Croft AK, Drennan CL. Dowling DP, et al. Annu Rev Biophys. 2012;41:403-27. doi: 10.1146/annurev-biophys-050511-102225. Annu Rev Biophys. 2012. PMID: 22577824 Review.

3

Structural diversity in the AdoMet radical enzyme superfamily.

Dowling DP, Vey JL, Croft AK, Drennan CL. Dowling DP, et al. Biochim Biophys Acta. 2012 Nov;1824(11):1178-95. doi: 10.1016/j.bbapap.2012.04.006. Epub 2012 Apr 28. Biochim Biophys Acta. 2012. PMID: 22579873 Free PMC article. Review.

4

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.

Dowling DP, Bruender NA, Young AP, McCarty RM, Bandarian V, Drennan CL. Dowling DP, et al. Nat Chem Biol. 2014 Feb;10(2):106-12. doi: 10.1038/nchembio.1426. Epub 2013 Dec 22. Nat Chem Biol. 2014. PMID: 24362703 Free PMC article.

5

Molecular basis of cobalamin-dependent RNA modification.

Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V, Drennan CL. Dowling DP, et al. Nucleic Acids Res. 2016 Nov 16;44(20):9965-9976. doi: 10.1093/nar/gkw806. Epub 2016 Sep 15. Nucleic Acids Res. 2016. PMID: 27638883 Free PMC article.

6

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL. Dowling DP, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12432-12437. doi: 10.1073/pnas.1608615113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791103 Free PMC article.

7

7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies.

Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL, Bandarian V. Bruender NA, et al. Among authors: dowling dp. J Am Chem Soc. 2017 Feb 8;139(5):1912-1920. doi: 10.1021/jacs.6b11381. Epub 2017 Jan 25. J Am Chem Soc. 2017. PMID: 28045519 Free PMC article.

8

Pathways of thymidine hypermodification.

Lee YJ, Dai N, Müller SI, Guan C, Parker MJ, Fraser ME, Walsh SE, Sridar J, Mulholland A, Nayak K, Sun Z, Lin YC, Comb DG, Marks K, Gonzalez R, Dowling DP, Bandarian V, Saleh L, Corrêa IR, Weigele PR. Lee YJ, et al. Among authors: dowling dp. Nucleic Acids Res. 2022 Apr 8;50(6):3001-3017. doi: 10.1093/nar/gkab781. Nucleic Acids Res. 2022. PMID: 34522950 Free PMC article.

9

Structure and function of the two-component flavin-dependent methanesulfinate monooxygenase within bacterial sulfur assimilation.

Soule J, Gnann AD, Gonzalez R, Parker MJ, McKenna KC, Nguyen SV, Phan NT, Wicht DK, Dowling DP. Soule J, et al. Among authors: dowling dp. Biochem Biophys Res Commun. 2020 Jan 29;522(1):107-112. doi: 10.1016/j.bbrc.2019.11.008. Epub 2019 Nov 18. Biochem Biophys Res Commun. 2020. PMID: 31753487

10

Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.

Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Cole KE, et al. Among authors: dowling dp. J Am Chem Soc. 2011 Aug 17;133(32):12474-7. doi: 10.1021/ja205972n. Epub 2011 Jul 26. J Am Chem Soc. 2011. PMID: 21790156 Free PMC article.

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