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Page 1
Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.
Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ. Bobkov V, et al. Among authors: smit mj. Biochem Pharmacol. 2018 Dec;158:413-424. doi: 10.1016/j.bcp.2018.10.014. Epub 2018 Oct 17. Biochem Pharmacol. 2018. PMID: 30342023 Free article.
Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor.
de Kruijf P, van Heteren J, Lim HD, Conti PG, van der Lee MM, Bosch L, Ho KK, Auld D, Ohlmeyer M, Smit MJ, Wijkmans JC, Zaman GJ, Smit MJ, Leurs R. de Kruijf P, et al. Among authors: smit mj. J Pharmacol Exp Ther. 2009 May;329(2):783-90. doi: 10.1124/jpet.108.148387. Epub 2009 Feb 3. J Pharmacol Exp Ther. 2009. PMID: 19190236
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.
Jähnichen S, Blanchetot C, Maussang D, Gonzalez-Pajuelo M, Chow KY, Bosch L, De Vrieze S, Serruys B, Ulrichts H, Vandevelde W, Saunders M, De Haard HJ, Schols D, Leurs R, Vanlandschoot P, Verrips T, Smit MJ. Jähnichen S, et al. Among authors: smit mj. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20565-70. doi: 10.1073/pnas.1012865107. Epub 2010 Nov 8. Proc Natl Acad Sci U S A. 2010. PMID: 21059953 Free PMC article.
Pharmacological modulation of chemokine receptor function.
Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R. Scholten DJ, et al. Among authors: smit mj. Br J Pharmacol. 2012 Mar;165(6):1617-1643. doi: 10.1111/j.1476-5381.2011.01551.x. Br J Pharmacol. 2012. PMID: 21699506 Free PMC article. Review.
Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes.
Watts AO, van Lipzig MM, Jaeger WC, Seeber RM, van Zwam M, Vinet J, van der Lee MM, Siderius M, Zaman GJ, Boddeke HW, Smit MJ, Pfleger KD, Leurs R, Vischer HF. Watts AO, et al. Among authors: smit mj. Br J Pharmacol. 2013 Apr;168(7):1662-74. doi: 10.1111/bph.12064. Br J Pharmacol. 2013. PMID: 23170857 Free PMC article.
Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.
Maussang D, Mujić-Delić A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ. Maussang D, et al. Among authors: smit mj. J Biol Chem. 2013 Oct 11;288(41):29562-72. doi: 10.1074/jbc.M113.498436. Epub 2013 Aug 26. J Biol Chem. 2013. PMID: 23979133 Free PMC article.
268 results