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ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
Yang J, Zhang Z, Zhang Y, Ni X, Zhang G, Cui X, Liu M, Xu C, Zhang Q, Zhu H, Yan J, Zhu VF, Luo Y, Hagan JP, Li Z, Fang J, Jatoi A, Fernandez-Zapico ME, Zheng L, Edil BH, Bronze MS, Houchen CW, Li YP, Li M. Yang J, et al. Gastroenterology. 2019 Feb;156(3):722-734.e6. doi: 10.1053/j.gastro.2018.10.026. Epub 2018 Oct 17. Gastroenterology. 2019. PMID: 30342032 Free PMC article.
Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice.
Aggarwal G, Ramachandran V, Javeed N, Arumugam T, Dutta S, Klee GG, Klee EW, Smyrk TC, Bamlet W, Han JJ, Rumie Vittar NB, de Andrade M, Mukhopadhyay D, Petersen GM, Fernandez-Zapico ME, Logsdon CD, Chari ST. Aggarwal G, et al. Gastroenterology. 2012 Dec;143(6):1510-1517.e1. doi: 10.1053/j.gastro.2012.08.044. Epub 2012 Sep 6. Gastroenterology. 2012. PMID: 22960655 Free PMC article.
A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.
Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. Zhang Y, et al. EMBO Mol Med. 2013 Sep;5(9):1322-34. doi: 10.1002/emmm.201302507. Epub 2013 Jul 16. EMBO Mol Med. 2013. PMID: 23857777 Free PMC article.
Epigenetics of cancer-associated muscle catabolism.
Carr RM, Enriquez-Hesles E, Olson RL, Jatoi A, Doles J, Fernandez-Zapico ME. Carr RM, et al. Epigenomics. 2017 Oct;9(10):1259-1265. doi: 10.2217/epi-2017-0058. Epub 2017 Sep 25. Epigenomics. 2017. PMID: 28942676
ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.
Liu M, Yang J, Zhang Y, Zhou Z, Cui X, Zhang L, Fung KM, Zheng W, Allard FD, Yee EU, Ding K, Wu H, Liang Z, Zheng L, Fernandez-Zapico ME, Li YP, Bronze MS, Morris KT, Postier RG, Houchen CW, Yang J, Li M. Liu M, et al. Clin Cancer Res. 2018 Jul 1;24(13):3186-3196. doi: 10.1158/1078-0432.CCR-18-0263. Epub 2018 Apr 3. Clin Cancer Res. 2018. PMID: 29615456 Free PMC article.
ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells.
Liu M, Zhang Y, Yang J, Cui X, Zhou Z, Zhan H, Ding K, Tian X, Yang Z, Fung KA, Edil BH, Postier RG, Bronze MS, Fernandez-Zapico ME, Stemmler MP, Brabletz T, Li YP, Houchen CW, Li M. Liu M, et al. Gastroenterology. 2020 Feb;158(3):679-692.e1. doi: 10.1053/j.gastro.2019.10.038. Epub 2019 Nov 9. Gastroenterology. 2020. PMID: 31711924 Free PMC article.
179 results