DeNizio JE - Search Results

1

Selectivity and Promiscuity in TET-Mediated Oxidation of 5-Methylcytosine in DNA and RNA.

DeNizio JE, Liu MY, Leddin EM, Cisneros GA, Kohli RM. DeNizio JE, et al. Biochemistry. 2019 Feb 5;58(5):411-421. doi: 10.1021/acs.biochem.8b00912. Epub 2018 Nov 14. Biochemistry. 2019. PMID: 30387995 Free PMC article.

2

The expanding scope and impact of epigenetic cytosine modifications.

Liu MY, DeNizio JE, Schutsky EK, Kohli RM. Liu MY, et al. Among authors: denizio je. Curr Opin Chem Biol. 2016 Aug;33:67-73. doi: 10.1016/j.cbpa.2016.05.029. Epub 2016 Jun 14. Curr Opin Chem Biol. 2016. PMID: 27315338 Free PMC article. Review.

3

Quantification of Oxidized 5-Methylcytosine Bases and TET Enzyme Activity.

Liu MY, DeNizio JE, Kohli RM. Liu MY, et al. Among authors: denizio je. Methods Enzymol. 2016;573:365-85. doi: 10.1016/bs.mie.2015.12.006. Epub 2016 Feb 1. Methods Enzymol. 2016. PMID: 27372762 Free PMC article.

4

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.

Liu MY, Torabifard H, Crawford DJ, DeNizio JE, Cao XJ, Garcia BA, Cisneros GA, Kohli RM. Liu MY, et al. Among authors: denizio je. Nat Chem Biol. 2017 Feb;13(2):181-187. doi: 10.1038/nchembio.2250. Epub 2016 Dec 5. Nat Chem Biol. 2017. PMID: 27918559 Free PMC article.

5

DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia.

Nabel CS, DeNizio JE, Carroll M, Kohli RM. Nabel CS, et al. Among authors: denizio je. Biochemistry. 2017 Apr 25;56(16):2166-2169. doi: 10.1021/acs.biochem.7b00208. Epub 2017 Apr 12. Biochemistry. 2017. PMID: 28394581 Free PMC article.

6

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.

Schutsky EK, Nabel CS, Davis AKF, DeNizio JE, Kohli RM. Schutsky EK, et al. Among authors: denizio je. Nucleic Acids Res. 2017 Jul 27;45(13):7655-7665. doi: 10.1093/nar/gkx345. Nucleic Acids Res. 2017. PMID: 28472485 Free PMC article.

7

Harnessing natural DNA modifying activities for editing of the genome and epigenome.

DeNizio JE, Schutsky EK, Berrios KN, Liu MY, Kohli RM. DeNizio JE, et al. Curr Opin Chem Biol. 2018 Aug;45:10-17. doi: 10.1016/j.cbpa.2018.01.016. Epub 2018 Feb 13. Curr Opin Chem Biol. 2018. PMID: 29452938 Free PMC article. Review.

8

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.

Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ. Fraietta JA, et al. Among authors: denizio je. Nature. 2018 Jun;558(7709):307-312. doi: 10.1038/s41586-018-0178-z. Epub 2018 May 30. Nature. 2018. PMID: 29849141 Free PMC article.

9

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase.

Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM. Schutsky EK, et al. Among authors: denizio je. Nat Biotechnol. 2018 Oct 8:10.1038/nbt.4204. doi: 10.1038/nbt.4204. Online ahead of print. Nat Biotechnol. 2018. PMID: 30295673 Free PMC article.

10

Exploiting Substrate Promiscuity To Develop Activity-Based Probes for Ten-Eleven Translocation Family Enzymes.

Ghanty U, DeNizio JE, Liu MY, Kohli RM. Ghanty U, et al. Among authors: denizio je. J Am Chem Soc. 2018 Dec 19;140(50):17329-17332. doi: 10.1021/jacs.8b04722. Epub 2018 Dec 11. J Am Chem Soc. 2018. PMID: 30518204 Free PMC article.

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