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Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.
Ranjitkar S, Jones AK, Mostafavi M, Zwirko Z, Iartchouk O, Barnes SW, Walker JR, Willis TW, Lee PS, Dean CR. Ranjitkar S, et al. Among authors: lee ps. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01718-18. doi: 10.1128/AAC.01718-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30420483 Free PMC article.
Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Jones AK, Caughlan RE, Woods AL, Uehara K, Xie L, Barnes SW, Walker JR, Thompson KV, Ranjitkar S, Lee PS, Dean CR. Jones AK, et al. Among authors: lee ps. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01490-19. doi: 10.1128/AAC.01490-19. Print 2019 Dec 20. Antimicrob Agents Chemother. 2019. PMID: 31658970 Free PMC article.
Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
Han W, Ma X, Balibar CJ, Baxter Rath CM, Benton B, Bermingham A, Casey F, Chie-Leon B, Cho MK, Frank AO, Frommlet A, Ho CM, Lee PS, Li M, Lingel A, Ma S, Merritt H, Ornelas E, De Pascale G, Prathapam R, Prosen KR, Rasper D, Ruzin A, Sawyer WS, Shaul J, Shen X, Shia S, Steffek M, Subramanian S, Vo J, Wang F, Wartchow C, Uehara T. Han W, et al. Among authors: lee ps. J Am Chem Soc. 2020 Mar 4;142(9):4445-4455. doi: 10.1021/jacs.9b13530. Epub 2020 Feb 17. J Am Chem Soc. 2020. PMID: 32064871
Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.
Lee PS, Lapointe G, Madera AM, Simmons RL, Xu W, Yifru A, Tjandra M, Karur S, Rico A, Thompson K, Bojkovic J, Xie L, Uehara K, Liu A, Shu W, Bellamacina C, McKenney D, Morris L, Tonn GR, Osborne C, Benton BM, McDowell L, Fu J, Sweeney ZK. Lee PS, et al. J Med Chem. 2018 Oct 25;61(20):9360-9370. doi: 10.1021/acs.jmedchem.8b01287. Epub 2018 Oct 3. J Med Chem. 2018. PMID: 30226381
Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bagdanoff JT, Jain R, Han W, Zhu S, Madiera AM, Lee PS, Ma X, Poon D. Bagdanoff JT, et al. Among authors: lee ps. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3788-92. doi: 10.1016/j.bmcl.2015.07.091. Epub 2015 Jul 30. Bioorg Med Chem Lett. 2015. PMID: 26259804
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M, Akçimen F, Grant SM, Akerman SC, Lee PS, Faghri F, Leonard H, Kim JJ, Makarious MB, Koretsky MJ, Rothstein JD, Blauwendraat C, Nalls MA, Singleton A, Bandres-Ciga S. Khani M, et al. Among authors: lee ps. medRxiv [Preprint]. 2024 Nov 17:2024.11.03.24313587. doi: 10.1101/2024.11.03.24313587. medRxiv. 2024. PMID: 39606324 Free PMC article. Preprint.
Large language models surpass human experts in predicting neuroscience results.
Luo X, Rechardt A, Sun G, Nejad KK, Yáñez F, Yilmaz B, Lee K, Cohen AO, Borghesani V, Pashkov A, Marinazzo D, Nicholas J, Salatiello A, Sucholutsky I, Minervini P, Razavi S, Rocca R, Yusifov E, Okalova T, Gu N, Ferianc M, Khona M, Patil KR, Lee PS, Mata R, Myers NE, Bizley JK, Musslick S, Bilgin IP, Niso G, Ales JM, Gaebler M, Ratan Murty NA, Loued-Khenissi L, Behler A, Hall CM, Dafflon J, Bao SD, Love BC. Luo X, et al. Among authors: lee ps. Nat Hum Behav. 2024 Nov 27. doi: 10.1038/s41562-024-02046-9. Online ahead of print. Nat Hum Behav. 2024. PMID: 39604572
688 results