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SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.
Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT. Leiris S, et al. Among authors: jennings n. ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30. ACS Infect Dis. 2019. PMID: 30427656 Free PMC article.
Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Cramp S, Dyke HJ, Higgs C, Clark DE, Gill M, Savy P, Jennings N, Price S, Lockey PM, Norman D, Porres S, Wilson F, Jones A, Ramsden N, Mangano R, Leggate D, Andersson M, Hale R. Cramp S, et al. Among authors: jennings n. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. doi: 10.1016/j.bmcl.2010.02.097. Epub 2010 Mar 3. Bioorg Med Chem Lett. 2010. PMID: 20299215
The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.
Bennett JM, Campbell AD, Campbell AJ, Carr MG, Dunsdon RM, Greening JR, Hurst DN, Jennings NS, Jones PS, Jordan S, Kay PB, O'Brien MA, King-Underwood J, Raynham TM, Wilkinson CS, Wilkinson TC, Wilson FX. Bennett JM, et al. Among authors: jennings ns. Bioorg Med Chem Lett. 2001 Feb 12;11(3):355-7. doi: 10.1016/s0960-894x(00)00654-5. Bioorg Med Chem Lett. 2001. PMID: 11212109
The design and synthesis of potent inhibitors of hepatitis C virus NS3-4A proteinase.
Attwood MR, Bennett JM, Campbell AD, Canning GG, Carr MG, Conway E, Dunsdon RM, Greening JR, Jones PS, Kay PB, Handa BK, Hurst DN, Jennings NS, Jordan S, Keech E, O'Brien MA, Overton HA, King-Underwood J, Raynham TM, Stenson KP, Wilkinson CS, Wilkinson TC, Wilson FX. Attwood MR, et al. Among authors: jennings ns. Antivir Chem Chemother. 1999 Sep;10(5):259-73. doi: 10.1177/095632029901000505. Antivir Chem Chemother. 1999. PMID: 10574181 Free article.
Endothelial p130cas confers resistance to anti-angiogenesis therapy.
Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Wen Y, et al. Among authors: jennings nb. Cell Rep. 2023 Mar 28;42(3):112154. doi: 10.1016/j.celrep.2023.112154. Cell Rep. 2023. PMID: 37274180 Free PMC article. No abstract available.
235 results