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Page 1
A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation.
De Bruyne M, Hoste L, Bogaert DJ, Van den Bossche L, Tavernier SJ, Parthoens E, Migaud M, Konopnicki D, Yombi JC, Lambrecht BN, van Daele S, Alves de Medeiros AK, Brochez L, Beyaert R, De Baere E, Puel A, Casanova JL, Goffard JC, Savvides SN, Haerynck F, Staal J, Dullaers M. De Bruyne M, et al. Among authors: savvides sn. Front Immunol. 2018 Oct 31;9:2366. doi: 10.3389/fimmu.2018.02366. eCollection 2018. Front Immunol. 2018. PMID: 30429846 Free PMC article.
Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.
Funcke JB, Moepps B, Roos J, von Schnurbein J, Verstraete K, Fröhlich-Reiterer E, Kohlsdorf K, Nunziata A, Brandt S, Tsirigotaki A, Dansercoer A, Suppan E, Haris B, Debatin KM, Savvides SN, Farooqi IS, Hussain K, Gierschik P, Fischer-Posovszky P, Wabitsch M. Funcke JB, et al. Among authors: savvides sn. N Engl J Med. 2023 Jun 15;388(24):2253-2261. doi: 10.1056/NEJMoa2204041. N Engl J Med. 2023. PMID: 37314706
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.
Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, Vandersarren L, Janssens S, Ramou I, Savvides SN, Haigh JJ, Hendriks R, Kopf M, Craessaerts K, de Strooper B, Kearney JF, Conrad DH, Lambrecht BN. Hammad H, et al. Among authors: savvides sn. Nat Immunol. 2017 Mar;18(3):313-320. doi: 10.1038/ni.3657. Epub 2017 Jan 9. Nat Immunol. 2017. PMID: 28068307 Free article.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN. Verstraete K, et al. Among authors: savvides sn. Nat Commun. 2017 Apr 3;8:14937. doi: 10.1038/ncomms14937. Nat Commun. 2017. PMID: 28368013 Free PMC article.
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.
Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M, Adamopoulos IE, Savvides SN. Bloch Y, et al. Among authors: savvides sn. Immunity. 2018 Jan 16;48(1):45-58.e6. doi: 10.1016/j.immuni.2017.12.008. Epub 2017 Dec 26. Immunity. 2018. PMID: 29287995 Free PMC article.
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB. Govindarajan S, et al. Among authors: savvides sn. Nat Commun. 2018 Dec 17;9(1):5340. doi: 10.1038/s41467-018-07758-x. Nat Commun. 2018. PMID: 30559399 Free PMC article.
IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation.
Holgado A, Braun H, Van Nuffel E, Detry S, Schuijs MJ, Deswarte K, Vergote K, Haegman M, Baudelet G, Haustraete J, Hammad H, Lambrecht BN, Savvides SN, Afonina IS, Beyaert R. Holgado A, et al. Among authors: savvides sn. J Allergy Clin Immunol. 2019 Jul;144(1):204-215. doi: 10.1016/j.jaci.2019.02.028. Epub 2019 Mar 13. J Allergy Clin Immunol. 2019. PMID: 30876911 Free PMC article.
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis.
Slowicka K, Serramito-Gómez I, Boada-Romero E, Martens A, Sze M, Petta I, Vikkula HK, De Rycke R, Parthoens E, Lippens S, Savvides SN, Wullaert A, Vereecke L, Pimentel-Muiños FX, van Loo G. Slowicka K, et al. Among authors: savvides sn. Nat Commun. 2019 Apr 23;10(1):1834. doi: 10.1038/s41467-019-09667-z. Nat Commun. 2019. PMID: 31015422 Free PMC article.
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN. Persson EK, et al. Among authors: savvides sn. Science. 2019 May 24;364(6442):eaaw4295. doi: 10.1126/science.aaw4295. Science. 2019. PMID: 31123109
137 results