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Page 1
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V, Milà-Guasch M, Millan J, Wiesner C, Serra H, Muixi L, Casanovas O, Viñals F, Affolter M, Gerhardt H, Huveneers S, Belting HG, Cutillas PR, Graupera M. Angulo-Urarte A, et al. Among authors: kobialka p. Nat Commun. 2018 Nov 16;9(1):4826. doi: 10.1038/s41467-018-07172-3. Nat Commun. 2018. PMID: 30446640 Free PMC article.
Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling.
Figueiredo AM, Villacampa P, Diéguez-Hurtado R, José Lozano J, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M. Figueiredo AM, et al. Among authors: kobialka p. Circulation. 2020 Aug 18;142(7):688-704. doi: 10.1161/CIRCULATIONAHA.119.042354. Epub 2020 May 29. Circulation. 2020. PMID: 32466671
Revisiting PI3-kinase signalling in angiogenesis.
Kobialka P, Graupera M. Kobialka P, et al. Vasc Biol. 2019 Nov 29;1(1):H125-H134. doi: 10.1530/VB-19-0025. eCollection 2019. Vasc Biol. 2019. PMID: 32923964 Free PMC article. Review.
The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib.
Kobialka P, Sabata H, Vilalta O, Gouveia L, Angulo-Urarte A, Muixí L, Zanoncello J, Muñoz-Aznar O, Olaciregui NG, Fanlo L, Esteve-Codina A, Lavarino C, Javierre BM, Celis V, Rovira C, López-Fernández S, Baselga E, Mora J, Castillo SD, Graupera M. Kobialka P, et al. EMBO Mol Med. 2022 Jul 7;14(7):e15619. doi: 10.15252/emmm.202115619. Epub 2022 Jun 13. EMBO Mol Med. 2022. PMID: 35695059 Free PMC article.
PI3K-C2β limits mTORC1 signaling and angiogenic growth.
Kobialka P, Llena J, Deleyto-Seldas N, Munar-Gelabert M, Dengra JA, Villacampa P, Albinyà-Pedrós A, Muixi L, Andrade J, van Splunder H, Angulo-Urarte A, Potente M, Grego-Bessa J, Castillo SD, Vanhaesebroeck B, Efeyan A, Graupera M. Kobialka P, et al. Sci Signal. 2023 Nov 28;16(813):eadg1913. doi: 10.1126/scisignal.adg1913. Epub 2023 Nov 28. Sci Signal. 2023. PMID: 38015911
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis.
Llaó-Cid C, Peguera B, Kobialka P, Decker L, Vogenstahl J, Alivodej N, Srivastava S, Jin J, Kirchmaier BC, Milla C, Schlierbach H, Schänzer A, Acker T, Segarra M, Acker-Palmer A. Llaó-Cid C, et al. Among authors: kobialka p. Nat Commun. 2024 Nov 29;15(1):10372. doi: 10.1038/s41467-024-54570-x. Nat Commun. 2024. PMID: 39609404