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Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.
Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC. Pitarresi JR, et al. Among authors: leone g. Life Sci Alliance. 2018 Oct 26;1(5):e201800190. doi: 10.26508/lsa.201800190. eCollection 2018 Oct. Life Sci Alliance. 2018. PMID: 30456390 Free PMC article.
Extra-embryonic function of Rb is essential for embryonic development and viability.
Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G. Wu L, et al. Among authors: leone g. Nature. 2003 Feb 27;421(6926):942-7. doi: 10.1038/nature01417. Nature. 2003. PMID: 12607001
Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.
Opavsky R, Tsai SY, Guimond M, Arora A, Opavska J, Becknell B, Kaufmann M, Walton NA, Stephens JA, Fernandez SA, Muthusamy N, Felsher DW, Porcu P, Caligiuri MA, Leone G. Opavsky R, et al. Among authors: leone g. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15400-5. doi: 10.1073/pnas.0706307104. Epub 2007 Sep 19. Proc Natl Acad Sci U S A. 2007. PMID: 17881568 Free PMC article.
Direct evidence for epithelial-mesenchymal transitions in breast cancer.
Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC, Leone G. Trimboli AJ, et al. Among authors: leone g. Cancer Res. 2008 Feb 1;68(3):937-45. doi: 10.1158/0008-5472.CAN-07-2148. Cancer Res. 2008. PMID: 18245497
Mouse development with a single E2F activator.
Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G. Tsai SY, et al. Among authors: leone g. Nature. 2008 Aug 28;454(7208):1137-41. doi: 10.1038/nature07066. Epub 2008 Jun 25. Nature. 2008. PMID: 18594513 Free PMC article.
1,348 results