Tochio N - Search Results

1

Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides.

Tochio N, Murata T, Utsunomiya-Tate N. Tochio N, et al. Biochem Biophys Res Commun. 2019 Jan 1;508(1):184-190. doi: 10.1016/j.bbrc.2018.11.043. Epub 2018 Nov 22. Biochem Biophys Res Commun. 2019. PMID: 30471859

2

The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation.

Ikura T, Tochio N, Kawasaki R, Matsuzaki M, Narita A, Kikumoto M, Utsunomiya-Tate N, Tate SI, Ito N. Ikura T, et al. Among authors: tochio n. FEBS Lett. 2018 Sep;592(18):3082-3091. doi: 10.1002/1873-3468.13218. Epub 2018 Aug 13. FEBS Lett. 2018. PMID: 30079475 Free article.

3

Physicochemical characterization of the G51D mutation of α-synuclein that is responsible for its severe cytotoxicity.

Murata T, Tochio N, Utsunomiya-Tate N. Murata T, et al. Among authors: tochio n. Neurosci Lett. 2021 Aug 24;760:136077. doi: 10.1016/j.neulet.2021.136077. Epub 2021 Jun 20. Neurosci Lett. 2021. PMID: 34161822

4

Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase.

Wang J, Tochio N, Kawasaki R, Tamari Y, Xu N, Uewaki J, Utsunomiya-Tate N, Tate S. Wang J, et al. Among authors: tochio n. Biochemistry. 2015 Aug 25;54(33):5242-53. doi: 10.1021/acs.biochem.5b00606. Epub 2015 Aug 13. Biochemistry. 2015. PMID: 26226559

5

The C113D mutation in human Pin1 causes allosteric structural changes in the phosphate binding pocket of the PPIase domain through the tug of war in the dual-histidine motif.

Xu N, Tochio N, Wang J, Tamari Y, Uewaki J, Utsunomiya-Tate N, Igarashi K, Shiraki T, Kobayashi N, Tate S. Xu N, et al. Among authors: tochio n. Biochemistry. 2014 Sep 2;53(34):5568-78. doi: 10.1021/bi5007817. Epub 2014 Aug 20. Biochemistry. 2014. PMID: 25100325

6

A fluorogenic peptide probe developed by in vitro selection using tRNA carrying a fluorogenic amino acid.

Wang W, Uzawa T, Tochio N, Hamatsu J, Hirano Y, Tada S, Saneyoshi H, Kigawa T, Hayashi N, Ito Y, Taiji M, Aigaki T, Ito Y. Wang W, et al. Among authors: tochio n. Chem Commun (Camb). 2014 Mar 18;50(22):2962-4. doi: 10.1039/c3cc47624c. Epub 2013 Dec 9. Chem Commun (Camb). 2014. PMID: 24317094

7

Comparison of residual alpha- and beta-structures between two intrinsically disordered proteins by using NMR.

Ono Y, Miyashita M, Ono Y, Okazaki H, Watanabe S, Tochio N, Kigawa T, Nishimura C. Ono Y, et al. Among authors: tochio n. Biochim Biophys Acta. 2015 Mar;1854(3):229-38. doi: 10.1016/j.bbapap.2014.12.007. Epub 2014 Dec 16. Biochim Biophys Acta. 2015. PMID: 25523747

8

Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.

Umehara K, Hoshikawa M, Tochio N, Tate SI. Umehara K, et al. Among authors: tochio n. Molecules. 2018 Feb 27;23(3):528. doi: 10.3390/molecules23030528. Molecules. 2018. PMID: 29495458 Free PMC article.

9

ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.

Nagano M, Hoshino D, Koshiba S, Shuo T, Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T, Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M. Nagano M, et al. Among authors: tochio n. J Biol Chem. 2011 Sep 9;286(36):31598-609. doi: 10.1074/jbc.M110.199430. Epub 2011 Jul 15. J Biol Chem. 2011. PMID: 21768110 Free PMC article.

10

Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1.

Wang J, Kawasaki R, Uewaki JI, Rashid AUR, Tochio N, Tate SI. Wang J, et al. Among authors: tochio n. Molecules. 2017 Jun 15;22(6):992. doi: 10.3390/molecules22060992. Molecules. 2017. PMID: 28617332 Free PMC article.

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