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Page 1
Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome.
Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Schleifer G, et al. Among authors: zapol wm. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L391-L399. doi: 10.1152/ajplung.00419.2018. Epub 2018 Dec 6. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30520688 Free PMC article.
Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.
Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. Petersen B, et al. Among authors: zapol wm. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L300-8. doi: 10.1152/ajplung.00243.2007. Epub 2007 Nov 30. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18055842 Free article.
Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge.
Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM. Wepler M, et al. Among authors: zapol wm. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1213-L1221. doi: 10.1152/ajplung.00394.2016. Epub 2016 Nov 4. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27815261 Free PMC article.
Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.
Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Ferrari M, et al. Among authors: zapol wm. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4241-E4250. doi: 10.1073/pnas.1621511114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28483998 Free PMC article.
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Jain IH, et al. Among authors: zapol wm. Cell Metab. 2019 Oct 1;30(4):824-832.e3. doi: 10.1016/j.cmet.2019.07.006. Epub 2019 Aug 8. Cell Metab. 2019. PMID: 31402314 Free PMC article.
Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome.
Grange RMH, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper MK, Nakagawa A, Miyazaki Y, Hindle AG, Batten AJ, Wojtkiewicz GR, Schleifer G, Bagchi A, Marutani E, Malhotra R, Bloch DB, Ichinose F, Mootha VK, Zapol WM. Grange RMH, et al. Among authors: zapol wm. Mol Genet Metab. 2021 May;133(1):83-93. doi: 10.1016/j.ymgme.2021.03.005. Epub 2021 Mar 11. Mol Genet Metab. 2021. PMID: 33752971 Free PMC article.
Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.
Ichinose F, Ullrich R, Sapirstein A, Jones RC, Bonventre JV, Serhan CN, Bloch KD, Zapol WM. Ichinose F, et al. Among authors: zapol wm. J Clin Invest. 2002 Jun;109(11):1493-500. doi: 10.1172/JCI14294. J Clin Invest. 2002. PMID: 12045263 Free PMC article.
317 results