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The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.
Inoue MK, Yamamotoya T, Nakatsu Y, Ueda K, Inoue Y, Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Morii K, Sasaki K, Masaki T, Suzuki Y, Asano T, Kushiyama A. Inoue MK, et al. Among authors: ueda k. Int J Mol Sci. 2018 Dec 10;19(12):3967. doi: 10.3390/ijms19123967. Int J Mol Sci. 2018. PMID: 30544662 Free PMC article.
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.
Nakatsu Y, Kokubo H, Bumdelger B, Yoshizumi M, Yamamotoya T, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Fujishiro M, Kushiyama A, Ono H, Sakoda H, Asano T. Nakatsu Y, et al. Among authors: ueda k. Int J Mol Sci. 2017 Aug 4;18(8):1704. doi: 10.3390/ijms18081704. Int J Mol Sci. 2017. PMID: 28777298 Free PMC article.
Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
Mizuno Y, Yamamotoya T, Nakatsu Y, Ueda K, Matsunaga Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kikuchi T, Takahashi M, Morii K, Sasaki K, Masaki T, Asano T, Kushiyama A. Mizuno Y, et al. Among authors: ueda k. Int J Mol Sci. 2019 Sep 21;20(19):4680. doi: 10.3390/ijms20194680. Int J Mol Sci. 2019. PMID: 31546603 Free PMC article.
Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.
Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T. Kushiyama A, et al. Among authors: ueda k. Mediators Inflamm. 2016;2016:8603164. doi: 10.1155/2016/8603164. Epub 2016 Dec 14. Mediators Inflamm. 2016. PMID: 28070145 Free PMC article. Review.
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T. Nakatsu Y, et al. Among authors: ueda k. J Biol Chem. 2017 Jul 14;292(28):11886-11895. doi: 10.1074/jbc.M117.780726. Epub 2017 May 31. J Biol Chem. 2017. PMID: 28566287 Free PMC article.
Development of Pin1 Inhibitors and their Potential as Therapeutic Agents.
Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T. Nakatsu Y, et al. Among authors: ueda k. Curr Med Chem. 2020;27(20):3314-3329. doi: 10.2174/0929867325666181105120911. Curr Med Chem. 2020. PMID: 30394205 Review.
Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice.
Inoue MK, Matsunaga Y, Nakatsu Y, Yamamotoya T, Ueda K, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Iwashita M, Sano T, Nishimura F, Morii K, Sasaki K, Masaki T, Asano T. Inoue MK, et al. Among authors: ueda k. Diabetol Metab Syndr. 2019 Jul 22;11:57. doi: 10.1186/s13098-019-0454-6. eCollection 2019. Diabetol Metab Syndr. 2019. PMID: 31367234 Free PMC article.
5,548 results