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Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.
Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium; Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. Gandal MJ, et al. Among authors: zhang p. Science. 2018 Dec 14;362(6420):eaat8127. doi: 10.1126/science.aat8127. Science. 2018. PMID: 30545856 Free PMC article.
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling.
Amar M, Pramod AB, Yu NK, Herrera VM, Qiu LR, Moran-Losada P, Zhang P, Trujillo CA, Ellegood J, Urresti J, Chau K, Diedrich J, Chen J, Gutierrez J, Sebat J, Ramanathan D, Lerch JP, Yates JR 3rd, Muotri AR, Iakoucheva LM. Amar M, et al. Among authors: zhang p. Mol Psychiatry. 2021 Jul;26(7):3586-3613. doi: 10.1038/s41380-021-01052-x. Epub 2021 Mar 16. Mol Psychiatry. 2021. PMID: 33727673 Free PMC article.
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism.
Urresti J, Zhang P, Moran-Losada P, Yu NK, Negraes PD, Trujillo CA, Antaki D, Amar M, Chau K, Pramod AB, Diedrich J, Tejwani L, Romero S, Sebat J, Yates Iii JR, Muotri AR, Iakoucheva LM. Urresti J, et al. Among authors: zhang p. Mol Psychiatry. 2021 Dec;26(12):7560-7580. doi: 10.1038/s41380-021-01243-6. Epub 2021 Aug 26. Mol Psychiatry. 2021. PMID: 34433918 Free PMC article.
Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain.
Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H, Consortium P, Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ. Wen C, et al. Among authors: zhang p. medRxiv [Preprint]. 2023 Mar 6:2023.03.03.23286706. doi: 10.1101/2023.03.03.23286706. medRxiv. 2023. Update in: Science. 2024 May 24;384(6698):eadh0829. doi: 10.1126/science.adh0829 PMID: 36945630 Free PMC article. Updated. Preprint.
Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms.
Patowary A, Zhang P, Jops C, Vuong CK, Ge X, Hou K, Kim M, Gong N, Margolis M, Vo D, Wang X, Liu C, Pasaniuc B, Li JJ, Gandal MJ, de la Torre-Ubieta L. Patowary A, et al. Among authors: zhang p. bioRxiv [Preprint]. 2023 Oct 11:2023.03.25.534016. doi: 10.1101/2023.03.25.534016. bioRxiv. 2023. Update in: Science. 2024 May 24;384(6698):eadh7688. doi: 10.1126/science.adh7688 PMID: 36993726 Free PMC article. Updated. Preprint.
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