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Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.
Washburn N, Schwab I, Ortiz D, Bhatnagar N, Lansing JC, Medeiros A, Tyler S, Mekala D, Cochran E, Sarvaiya H, Garofalo K, Meccariello R, Meador JW 3rd, Rutitzky L, Schultes BC, Ling L, Avery W, Nimmerjahn F, Manning AM, Kaundinya GV, Bosques CJ. Washburn N, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1297-306. doi: 10.1073/pnas.1422481112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733881 Free PMC article.
A single glycan on IgE is indispensable for initiation of anaphylaxis.
Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. Shade KT, et al. Among authors: washburn n. J Exp Med. 2015 Apr 6;212(4):457-67. doi: 10.1084/jem.20142182. Epub 2015 Mar 30. J Exp Med. 2015. PMID: 25824821 Free PMC article.
Elucidating the interplay between IgG-Fc valency and FcγR activation for the design of immune complex inhibitors.
Ortiz DF, Lansing JC, Rutitzky L, Kurtagic E, Prod'homme T, Choudhury A, Washburn N, Bhatnagar N, Beneduce C, Holte K, Prenovitz R, Child M, Killough J, Tyler S, Brown J, Nguyen S, Schwab I, Hains M, Meccariello R, Markowitz L, Wang J, Zouaoui R, Simpson A, Schultes B, Capila I, Ling L, Nimmerjahn F, Manning AM, Bosques CJ. Ortiz DF, et al. Among authors: washburn n. Sci Transl Med. 2016 Nov 16;8(365):365ra158. doi: 10.1126/scitranslmed.aaf9418. Sci Transl Med. 2016. PMID: 27856797
Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor.
Farutin V, Prod'homme T, McConnell K, Washburn N, Halvey P, Etzel CJ, Guess J, Duffner J, Getchell K, Meccariello R, Gutierrez B, Honan C, Zhao G, Cilfone NA, Gunay NS, Hillson JL, DeLuca DS, Saunders KC, Pappas DA, Greenberg JD, Kremer JM, Manning AM, Ling LE, Capila I. Farutin V, et al. Among authors: washburn n. Arthritis Res Ther. 2019 Oct 23;21(1):216. doi: 10.1186/s13075-019-1999-3. Arthritis Res Ther. 2019. PMID: 31647025 Free PMC article. Clinical Trial.
[No title available]
[No authors listed] [No authors listed] PMID: 33431127
82 results