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Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K. Papatheodorou P, et al. Among authors: ost gs. FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28. FASEB J. 2019. PMID: 30592645

Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins.

Ost GS, Wirth C, Bogdanović X, Kao WC, Schorch B, Aktories PJK, Papatheodorou P, Schwan C, Schlosser A, Jank T, Hunte C, Aktories K. Ost GS, et al. Sci Adv. 2020 Mar 11;6(11):eaaz2094. doi: 10.1126/sciadv.aaz2094. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32195351 Free PMC article.

Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells.

Ost GS, Ng'ang'a PN, Lang AE, Aktories K. Ost GS, et al. Cell Microbiol. 2019 Mar;21(3):e12978. doi: 10.1111/cmi.12978. Epub 2018 Dec 2. Cell Microbiol. 2019. PMID: 30431706

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