Cheng G - Search Results

1

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Dong XW, Zhang JK, Xu L, Che JX, Cheng G, Hu XB, Sheng L, Gao AH, Li J, Liu T, Hu YZ, Zhou YB. Dong XW, et al. Among authors: cheng g. Eur J Med Chem. 2019 Feb 15;164:602-614. doi: 10.1016/j.ejmech.2018.12.064. Epub 2018 Dec 26. Eur J Med Chem. 2019. PMID: 30639896

2

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.

Dong X, Zhan W, Zhao M, Che J, Dai X, Wu Y, Xu L, Zhou Y, Zhao Y, Tian T, Cheng G, Jin Z, Li J, Shao Y, He Q, Yang B, Weng Q, Hu Y. Dong X, et al. Among authors: cheng g. J Med Chem. 2019 Aug 8;62(15):7264-7288. doi: 10.1021/acs.jmedchem.9b00891. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31298542

3

Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.

Zhan W, Che J, Xu L, Wu Y, Hu X, Zhou Y, Cheng G, Hu Y, Dong X, Li J. Zhan W, et al. Among authors: cheng g. Eur J Med Chem. 2019 Oct 15;180:72-85. doi: 10.1016/j.ejmech.2019.07.017. Epub 2019 Jul 7. Eur J Med Chem. 2019. PMID: 31301565

4

Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening.

Gu D, Cheng G, Zhang M, Zhou YB, Li J, Sheng R. Gu D, et al. Among authors: cheng g. Bioorg Med Chem. 2021 Jan 1;29:115863. doi: 10.1016/j.bmc.2020.115863. Epub 2020 Nov 7. Bioorg Med Chem. 2021. PMID: 33199203

5

One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization.

Cheng G, Qi Y, Zhou X, Sheng R, Hu YZ, Hu Y. Cheng G, et al. Sci Rep. 2017 Jun 30;7(1):4398. doi: 10.1038/s41598-017-04693-7. Sci Rep. 2017. PMID: 28667287 Free PMC article.

6

Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold.

Chen J, He H, Wei A, Li Y, Cheng G, Qin H, Zhong H, Liu H, Geng M, Shen A, Hu Y. Chen J, et al. Among authors: cheng g. Eur J Med Chem. 2022 Jun 5;236:114259. doi: 10.1016/j.ejmech.2022.114259. Epub 2022 Mar 31. Eur J Med Chem. 2022. PMID: 35395439

7

Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease.

Cheng G, Xu P, Zhang M, Chen J, Sheng R, Ma Y. Cheng G, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5759-5765. doi: 10.1016/j.bmc.2018.08.011. Epub 2018 Aug 9. Bioorg Med Chem. 2018. PMID: 30360953

8

Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A.

Cheng G, Li S, Li J, Hu Y. Cheng G, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1177-80. doi: 10.1016/j.bmcl.2007.11.117. Epub 2007 Dec 4. Bioorg Med Chem Lett. 2008. PMID: 18160286

9

Valtrate as a novel therapeutic agent exhibits potent anti-pancreatic cancer activity by inhibiting Stat3 signaling.

Chen L, Feng D, Qian Y, Cheng X, Song H, Qian Y, Zhang X, Wu Y, Lv H, Liu Q, Cheng G, Yang B, Gu M. Chen L, et al. Among authors: cheng x, cheng g. Phytomedicine. 2021 May;85:153537. doi: 10.1016/j.phymed.2021.153537. Epub 2021 Mar 3. Phytomedicine. 2021. PMID: 33744595

10

Two efficient cascade reactions to synthesize substituted furocoumarins.

Cheng G, Hu Y. Cheng G, et al. J Org Chem. 2008 Jun 20;73(12):4732-5. doi: 10.1021/jo800439y. Epub 2008 May 28. J Org Chem. 2008. PMID: 18505287

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