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MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics.
Larrea D, Pera M, Gonnelli A, Quintana-Cabrera R, Akman HO, Guardia-Laguarta C, Velasco KR, Area-Gomez E, Dal Bello F, De Stefani D, Horvath R, Shy ME, Schon EA, Giacomello M. Larrea D, et al. Among authors: guardia laguarta c. Hum Mol Genet. 2019 Jun 1;28(11):1782-1800. doi: 10.1093/hmg/ddz008. Hum Mol Genet. 2019. PMID: 30649465 Free PMC article.
ApoE4 upregulates the activity of mitochondria-associated ER membranes.
Tambini MD, Pera M, Kanter E, Yang H, Guardia-Laguarta C, Holtzman D, Sulzer D, Area-Gomez E, Schon EA. Tambini MD, et al. EMBO Rep. 2016 Jan;17(1):27-36. doi: 10.15252/embr.201540614. Epub 2015 Nov 12. EMBO Rep. 2016. PMID: 26564908 Free PMC article.
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E. Pera M, et al. Among authors: guardia laguarta c. EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10. EMBO J. 2017. PMID: 29018038 Free PMC article.
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.
Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon EA. Area-Gomez E, et al. EMBO J. 2012 Nov 5;31(21):4106-23. doi: 10.1038/emboj.2012.202. Epub 2012 Aug 14. EMBO J. 2012. PMID: 22892566 Free PMC article.
α-Synuclein is localized to mitochondria-associated ER membranes.
Guardia-Laguarta C, Area-Gomez E, Rüb C, Liu Y, Magrané J, Becker D, Voos W, Schon EA, Przedborski S. Guardia-Laguarta C, et al. J Neurosci. 2014 Jan 1;34(1):249-59. doi: 10.1523/JNEUROSCI.2507-13.2014. J Neurosci. 2014. PMID: 24381286 Free PMC article.
The fat brain.
Montesinos J, Guardia-Laguarta C, Area-Gomez E. Montesinos J, et al. Among authors: guardia laguarta c. Curr Opin Clin Nutr Metab Care. 2020 Mar;23(2):68-75. doi: 10.1097/MCO.0000000000000634. Curr Opin Clin Nutr Metab Care. 2020. PMID: 32004239 Review.
29 results