Wang J - Search Results

1

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma.

Carlsson M, Braddock M, Li Y, Wang J, Xu W, White N, Megally A, Hunter G, Colice G. Carlsson M, et al. Among authors: wang j. Drug Saf. 2019 Jun;42(6):769-784. doi: 10.1007/s40264-018-00788-w. Drug Saf. 2019. PMID: 30649752 Free PMC article. Clinical Trial.

2

Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding.

Lu X, Machiesky LA, De Mel N, Du Q, Xu W, Washabaugh M, Jiang XR, Wang J. Lu X, et al. Among authors: wang j. Sci Rep. 2020 Jan 15;10(1):383. doi: 10.1038/s41598-019-57184-2. Sci Rep. 2020. PMID: 31941950 Free PMC article.

3

Monoclonal Antibody Sequence Variants Disguised as Fragments: Identification, Characterization, and Their Removal by Purification Process Optimization.

Delmar JA, Harris C, Grassi L, Macapagal N, Wang J, Hatton D, Xu W. Delmar JA, et al. Among authors: wang j. J Pharm Sci. 2022 Nov;111(11):3009-3016. doi: 10.1016/j.xphs.2022.08.002. Epub 2022 Aug 5. J Pharm Sci. 2022. PMID: 35940243 Free article.

4

A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins.

Xu W, Jimenez RB, Mowery R, Luo H, Cao M, Agarwal N, Ramos I, Wang X, Wang J. Xu W, et al. Among authors: wang x, wang j. MAbs. 2017 Oct;9(7):1186-1196. doi: 10.1080/19420862.2017.1364326. Epub 2017 Aug 14. MAbs. 2017. PMID: 28805536 Free PMC article.

5

Charge variants characterization and release assay development for co-formulated antibodies as a combination therapy.

Cao M, De Mel N, Shannon A, Prophet M, Wang C, Xu W, Niu B, Kim J, Albarghouthi M, Liu D, Meinke E, Lin S, Wang X, Wang J. Cao M, et al. Among authors: wang x, wang j, wang c. MAbs. 2019 Apr;11(3):489-499. doi: 10.1080/19420862.2019.1578137. Epub 2019 Feb 20. MAbs. 2019. PMID: 30786796 Free PMC article.

6

Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis.

Harris C, Xu W, Grassi L, Wang C, Markle A, Hardman C, Stevens R, Miro-Quesada G, Hatton D, Wang J. Harris C, et al. Among authors: wang j, wang c. MAbs. 2019 Nov-Dec;11(8):1452-1463. doi: 10.1080/19420862.2019.1667740. Epub 2019 Oct 1. MAbs. 2019. PMID: 31570042 Free PMC article.

7

Double-peak elution profile of a monoclonal antibody in cation exchange chromatography is caused by histidine-protonation-based charge variants.

Luo H, Cao M, Newell K, Afdahl C, Wang J, Wang WK, Li Y. Luo H, et al. Among authors: wang j, wang wk. J Chromatogr A. 2015 Dec 11;1424:92-101. doi: 10.1016/j.chroma.2015.11.008. Epub 2015 Nov 5. J Chromatogr A. 2015. PMID: 26596869 Free article.

8

An Automated and Qualified Platform Method for Site-Specific Succinimide and Deamidation Quantitation Using Low-pH Peptide Mapping.

Cao M, Xu W, Niu B, Kabundi I, Luo H, Prophet M, Chen W, Liu D, Saveliev SV, Urh M, Wang J. Cao M, et al. Among authors: wang j. J Pharm Sci. 2019 Nov;108(11):3540-3549. doi: 10.1016/j.xphs.2019.07.019. Epub 2019 Jul 30. J Pharm Sci. 2019. PMID: 31374319 Free article.

9

Analytical characterization of coformulated antibodies as combination therapy.

Kim J, Kim YJ, Cao M, De Mel N, Albarghouthi M, Miller K, Bee JS, Wang J, Wang X. Kim J, et al. Among authors: wang x, wang j. MAbs. 2020 Jan-Dec;12(1):1738691. doi: 10.1080/19420862.2020.1738691. MAbs. 2020. PMID: 32138591 Free PMC article.

10

Insights into the molecular basis of a bispecific antibody's target selectivity.

Mazor Y, Hansen A, Yang C, Chowdhury PS, Wang J, Stephens G, Wu H, Dall'Acqua WF. Mazor Y, et al. Among authors: wang j. MAbs. 2015;7(3):461-9. doi: 10.1080/19420862.2015.1022695. MAbs. 2015. PMID: 25730144 Free PMC article.

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