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Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.
Cumaraswamy AA, Lewis AM, Geletu M, Todic A, Diaz DB, Cheng XR, Brown CE, Laister RC, Muench D, Kerman K, Grimes HL, Minden MD, Gunning PT. Cumaraswamy AA, et al. Among authors: gunning pt. ACS Med Chem Lett. 2014 Sep 19;5(11):1202-1206. doi: 10.1021/ml500165r. eCollection 2014 Nov 13. ACS Med Chem Lett. 2014. PMID: 25419444 Free PMC article.
STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.
Singh M, Garg N, Venugopal C, Hallett R, Tokar T, McFarlane N, Mahendram S, Bakhshinyan D, Manoranjan B, Vora P, Qazi M, Arpin CC, Page B, Haftchenary S, Rosa DA, Lai PS, Gómez-Biagi RF, Ali AM, Lewis A, Geletu M, Murty NK, Hassell JA, Jurisica I, Gunning PT, Singh SK. Singh M, et al. Among authors: gunning pt. Oncotarget. 2015 Sep 29;6(29):27461-77. doi: 10.18632/oncotarget.4742. Oncotarget. 2015. PMID: 26314961 Free PMC article.
A selective inhibitor of the UFM1-activating enzyme, UBA5.
da Silva SR, Paiva SL, Bancerz M, Geletu M, Lewis AM, Chen J, Cai Y, Lukkarila JL, Li H, Gunning PT. da Silva SR, et al. Among authors: gunning pt. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4542-4547. doi: 10.1016/j.bmcl.2015.10.015. Epub 2015 Oct 8. Bioorg Med Chem Lett. 2016. PMID: 27520940
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
Shouksmith AE, Shah F, Grimard ML, Gawel JM, Raouf YS, Geletu M, Berger-Becvar A, de Araujo ED, Luchman HA, Heaton WL, Bakhshinyan D, Adile AA, Venugopal C, O'Hare T, Deininger MW, Singh SK, Konieczny SF, Weiss S, Fishel ML, Gunning PT. Shouksmith AE, et al. Among authors: gunning pt. J Med Chem. 2019 Mar 14;62(5):2651-2665. doi: 10.1021/acs.jmedchem.8b01957. Epub 2019 Mar 6. J Med Chem. 2019. PMID: 30776234 Free PMC article.
127 results