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Page 1
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens A, Greaves LC, Kolsky KL, Parini A, Douin-Echinard V, LeBrasseur NK, Arthur HM, Tual-Chalot S, Schafer MJ, Roos CM, Miller JD, Robertson N, Mann J, Adams PD, Tchkonia T, Kirkland JL, Mialet-Perez J, Richardson GD, Passos JF. Anderson R, et al. Among authors: dookun e. EMBO J. 2019 Mar 1;38(5):e100492. doi: 10.15252/embj.2018100492. Epub 2019 Feb 8. EMBO J. 2019. PMID: 30737259 Free PMC article.
Therapeutic Potential of Senolytics in Cardiovascular Disease.
Dookun E, Passos JF, Arthur HM, Richardson GD. Dookun E, et al. Cardiovasc Drugs Ther. 2022 Feb;36(1):187-196. doi: 10.1007/s10557-020-07075-w. Epub 2020 Sep 26. Cardiovasc Drugs Ther. 2022. PMID: 32979174 Free PMC article. Review.
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery.
Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep OE, Santin Y, Mialet-Perez J, Andrew Owens W, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Dookun E, et al. Aging Cell. 2020 Oct;19(10):e13249. doi: 10.1111/acel.13249. Epub 2020 Sep 29. Aging Cell. 2020. PMID: 32996233 Free PMC article.
Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells.
Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I. Richardson GD, et al. Among authors: dookun e. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1283-1296. doi: 10.1161/ATVBAHA.117.309940. Epub 2018 Mar 29. Arterioscler Thromb Vasc Biol. 2018. PMID: 29599138 Free PMC article.
Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction.
Redgrave R, Dookun E, Booth L, Folaranm O, Tual-Chalot S, Gill J, Owens A, Spyridopoulos I, Passos J, Richardson G. Redgrave R, et al. Among authors: dookun e. Res Sq [Preprint]. 2023 Apr 10:rs.3.rs-2776501. doi: 10.21203/rs.3.rs-2776501/v1. Res Sq. 2023. Update in: NPJ Aging. 2023 Jun 14;9(1):15. doi: 10.1038/s41514-023-00113-5. PMID: 37090497 Free PMC article. Updated. Preprint.