Bleasby K - Search Results

1

In Vitro Evaluation of the Drug Interaction Potential of Doravirine.

Bleasby K, Fillgrove KL, Houle R, Lu B, Palamanda J, Newton DJ, Lin M, Chan GH, Sanchez RI. Bleasby K, et al. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02492-18. doi: 10.1128/AAC.02492-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30745395 Free PMC article.

2

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters.

Bleasby K, Houle R, Hafey M, Lin M, Guo J, Lu B, Sanchez RI, Fillgrove KL. Bleasby K, et al. Viruses. 2021 Aug 7;13(8):1566. doi: 10.3390/v13081566. Viruses. 2021. PMID: 34452431 Free PMC article.

3

The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?

Chu X, Bleasby K, Chan GH, Nunes I, Evers R. Chu X, et al. Among authors: bleasby k. Drug Metab Dispos. 2016 Sep;44(9):1498-509. doi: 10.1124/dmd.115.067694. Epub 2016 Jan 29. Drug Metab Dispos. 2016. PMID: 26825641 Review.

4

Transporters affecting biochemical test results: Creatinine-drug interactions.

Chu X, Bleasby K, Chan GH, Nunes I, Evers R. Chu X, et al. Among authors: bleasby k. Clin Pharmacol Ther. 2016 Nov;100(5):437-440. doi: 10.1002/cpt.445. Epub 2016 Sep 15. Clin Pharmacol Ther. 2016. PMID: 27509262 Review.

5

Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein.

Chu XY, Bleasby K, Yabut J, Cai X, Chan GH, Hafey MJ, Xu S, Bergman AJ, Braun MP, Dean DC, Evers R. Chu XY, et al. Among authors: bleasby k. J Pharmacol Exp Ther. 2007 May;321(2):673-83. doi: 10.1124/jpet.106.116517. Epub 2007 Feb 21. J Pharmacol Exp Ther. 2007. PMID: 17314201

6

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure.

He H, Lyons KA, Shen X, Yao Z, Bleasby K, Chan G, Hafey M, Li X, Xu S, Salituro GM, Cohen LH, Tang W. He H, et al. Among authors: bleasby k. Xenobiotica. 2009 Sep;39(9):687-93. doi: 10.1080/00498250903015402. Xenobiotica. 2009. PMID: 19569734

7

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Lévesque JF, Bleasby K, Chefson A, Chen A, Dubé D, Ducharme Y, Fournier PA, Gagné S, Gallant M, Grimm E, Hafey M, Han Y, Houle R, Lacombe P, Laliberté S, MacDonald D, Mackay B, Papp R, Tschirret-Guth R. Lévesque JF, et al. Among authors: bleasby k. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5547-51. doi: 10.1016/j.bmcl.2011.06.095. Epub 2011 Jun 28. Bioorg Med Chem Lett. 2011. PMID: 21784634

8

Species differences in drug transporters and implications for translating preclinical findings to humans.

Chu X, Bleasby K, Evers R. Chu X, et al. Among authors: bleasby k. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):237-52. doi: 10.1517/17425255.2013.741589. Epub 2012 Dec 21. Expert Opin Drug Metab Toxicol. 2013. PMID: 23256482 Review.

9

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition.

Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF, Kulkarni AV, Hafey MJ, Evers R, Johnson JM, Ulrich RG, Slatter JG. Bleasby K, et al. Xenobiotica. 2006 Oct-Nov;36(10-11):963-88. doi: 10.1080/00498250600861751. Xenobiotica. 2006. PMID: 17118916

10

The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease.

Monteagudo E, Fonsi M, Chu X, Bleasby K, Evers R, Pucci V, Orsale MV, Cianetti S, Ferrara M, Harper S, Laufer R, Rowley M, Summa V. Monteagudo E, et al. Among authors: bleasby k. Xenobiotica. 2010 Dec;40(12):826-39. doi: 10.3109/00498254.2010.519061. Epub 2010 Oct 7. Xenobiotica. 2010. PMID: 20925584

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