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Page 1
A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.
Gagnon L, Leduc M, Thibodeau JF, Zhang MZ, Grouix B, Sarra-Bournet F, Gagnon W, Hince K, Tremblay M, Geerts L, Kennedy CRJ, Hébert RL, Gutsol A, Holterman CE, Kamto E, Gervais L, Ouboudinar J, Richard J, Felton A, Laverdure A, Simard JC, Létourneau S, Cloutier MP, Leblond FA, Abbott SD, Penney C, Duceppe JS, Zacharie B, Dupuis J, Calderone A, Nguyen QT, Harris RC, Laurin P. Gagnon L, et al. Among authors: laurin p. Am J Pathol. 2018 May;188(5):1132-1148. doi: 10.1016/j.ajpath.2018.01.009. Epub 2018 Feb 16. Am J Pathol. 2018. PMID: 29454750 Free article.
PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway.
Grouix B, Sarra-Bournet F, Leduc M, Simard JC, Hince K, Geerts L, Blais A, Gervais L, Laverdure A, Felton A, Richard J, Ouboudinar J, Gagnon W, Leblond FA, Laurin P, Gagnon L. Grouix B, et al. Among authors: laurin p. J Pharmacol Exp Ther. 2018 Oct;367(1):71-81. doi: 10.1124/jpet.118.250068. Epub 2018 Aug 9. J Pharmacol Exp Ther. 2018. PMID: 30093459
Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis.
Khalil N, Manganas H, Ryerson CJ, Shapera S, Cantin AM, Hernandez P, Turcotte EE, Parker JM, Moran JE, Albert GR, Sawtell R, Hagerimana A, Laurin P, Gagnon L, Cesari F, Kolb M. Khalil N, et al. Among authors: laurin p. Eur Respir J. 2019 Mar 18;53(3):1800663. doi: 10.1183/13993003.00663-2018. Print 2019 Mar. Eur Respir J. 2019. PMID: 30578394 Free PMC article. Clinical Trial.
Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease.
Simard JC, Thibodeau JF, Leduc M, Tremblay M, Laverdure A, Sarra-Bournet F, Gagnon W, Ouboudinar J, Gervais L, Felton A, Letourneau S, Geerts L, Cloutier MP, Hince K, Corpuz R, Blais A, Quintela VM, Duceppe JS, Abbott SD, Blais A, Zacharie B, Laurin P, Laplante SR, Kennedy CRJ, Hébert RL, Leblond FA, Grouix B, Gagnon L. Simard JC, et al. Among authors: laurin p. Sci Rep. 2020 Jul 29;10(1):12778. doi: 10.1038/s41598-020-69675-8. Sci Rep. 2020. PMID: 32728158 Free PMC article.
Fourteen-Day Evolution of COVID-19 Symptoms during the Third Wave in Nonvaccinated Subjects and Effects of Hesperidin Therapy: A Randomized, Double-Blinded, Placebo-Controlled Study.
Dupuis J, Laurin P, Tardif JC, Hausermann L, Rosa C, Guertin MC, Thibaudeau K, Gagnon L, Cesari F, Robitaille M, Moran JE. Dupuis J, et al. Among authors: laurin p. Evid Based Complement Alternat Med. 2022 Nov 3;2022:3125662. doi: 10.1155/2022/3125662. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 36387348 Free PMC article.
30 results