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48 results

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A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis.
Lukey PT, Harrison SA, Yang S, Man Y, Holman BF, Rashidnasab A, Azzopardi G, Grayer M, Simpson JK, Bareille P, Paul L, Woodcock HV, Toshner R, Saunders P, Molyneaux PL, Thielemans K, Wilson FJ, Mercer PF, Chambers RC, Groves AM, Fahy WA, Marshall RP, Maher TM. Lukey PT, et al. Among authors: simpson jk. Eur Respir J. 2019 Mar 18;53(3):1801992. doi: 10.1183/13993003.01992-2018. Print 2019 Mar. Eur Respir J. 2019. PMID: 30765508 Free article. Clinical Trial.
Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study.
Jenkins RG, Simpson JK, Saini G, Bentley JH, Russell AM, Braybrooke R, Molyneaux PL, McKeever TM, Wells AU, Flynn A, Hubbard RB, Leeming DJ, Marshall RP, Karsdal MA, Lukey PT, Maher TM. Jenkins RG, et al. Among authors: simpson jk. Lancet Respir Med. 2015 Jun;3(6):462-72. doi: 10.1016/S2213-2600(15)00048-X. Epub 2015 Mar 12. Lancet Respir Med. 2015. PMID: 25770676 Free article.
An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study.
Maher TM, Oballa E, Simpson JK, Porte J, Habgood A, Fahy WA, Flynn A, Molyneaux PL, Braybrooke R, Divyateja H, Parfrey H, Rassl D, Russell AM, Saini G, Renzoni EA, Duggan AM, Hubbard R, Wells AU, Lukey PT, Marshall RP, Jenkins RG. Maher TM, et al. Among authors: simpson jk. Lancet Respir Med. 2017 Dec;5(12):946-955. doi: 10.1016/S2213-2600(17)30430-7. Epub 2017 Nov 14. Lancet Respir Med. 2017. PMID: 29150411 Free article.
Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort.
Organ LA, Duggan AR, Oballa E, Taggart SC, Simpson JK, Kang'ombe AR, Braybrooke R, Molyneaux PL, North B, Karkera Y, Leeming DJ, Karsdal MA, Nanthakumar CB, Fahy WA, Marshall RP, Jenkins RG, Maher TM. Organ LA, et al. Among authors: simpson jk. Respir Res. 2019 Jul 12;20(1):148. doi: 10.1186/s12931-019-1118-7. Respir Res. 2019. PMID: 31299951 Free PMC article. Clinical Trial.
A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.
Maher TM, Simpson JK, Porter JC, Wilson FJ, Chan R, Eames R, Cui Y, Siederer S, Parry S, Kenny J, Slack RJ, Sahota J, Paul L, Saunders P, Molyneaux PL, Lukey PT, Rizzo G, Searle GE, Marshall RP, Saleem A, Kang'ombe AR, Fairman D, Fahy WA, Vahdati-Bolouri M. Maher TM, et al. Among authors: simpson jk. Respir Res. 2020 Mar 26;21(1):75. doi: 10.1186/s12931-020-01339-7. Respir Res. 2020. PMID: 32216814 Free PMC article. Clinical Trial.
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants.
Maden CH, Fairman D, Chalker M, Costa MJ, Fahy WA, Garman N, Lukey PT, Mant T, Parry S, Simpson JK, Slack RJ, Kendrick S, Marshall RP. Maden CH, et al. Among authors: simpson jk. Eur J Clin Pharmacol. 2018 Jun;74(6):701-709. doi: 10.1007/s00228-018-2435-3. Epub 2018 Mar 12. Eur J Clin Pharmacol. 2018. PMID: 29532104 Free PMC article. Clinical Trial.
Strategies for biomarker discovery in fibrotic disease.
Marshall RP, Simpson JK, Lukey PT. Marshall RP, et al. Among authors: simpson jk. Biochim Biophys Acta. 2013 Jul;1832(7):1079-87. doi: 10.1016/j.bbadis.2013.01.018. Epub 2013 Jan 31. Biochim Biophys Acta. 2013. PMID: 23376113 Free article. Review.
48 results