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Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.
Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, Carlsson LG, Peirce SM, Hu S. Sun N, et al. Among authors: holtta m. Sci Rep. 2018 Nov 30;8(1):17509. doi: 10.1038/s41598-018-35570-6. Sci Rep. 2018. PMID: 30504800 Free PMC article.
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells.
Maugeri M, Nawaz M, Papadimitriou A, Angerfors A, Camponeschi A, Na M, Hölttä M, Skantze P, Johansson S, Sundqvist M, Lindquist J, Kjellman T, Mårtensson IL, Jin T, Sunnerhagen P, Östman S, Lindfors L, Valadi H. Maugeri M, et al. Among authors: holtta m. Nat Commun. 2019 Sep 24;10(1):4333. doi: 10.1038/s41467-019-12275-6. Nat Commun. 2019. PMID: 31551417 Free PMC article.
An oral antisense oligonucleotide for PCSK9 inhibition.
Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Among authors: holtta m. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578
25 results