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Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.
Scala F, Fusco S, Ripoli C, Piacentini R, Li Puma DD, Spinelli M, Laezza F, Grassi C, D'Ascenzo M. Scala F, et al. Among authors: laezza f. Neurobiol Aging. 2015 Feb;36(2):886-900. doi: 10.1016/j.neurobiolaging.2014.10.034. Epub 2014 Nov 4. Neurobiol Aging. 2015. PMID: 25541422 Free PMC article.
CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitability.
Hsu WC, Scala F, Nenov MN, Wildburger NC, Elferink H, Singh AK, Chesson CB, Buzhdygan T, Sohail M, Shavkunov AS, Panova NI, Nilsson CL, Rudra JS, Lichti CF, Laezza F. Hsu WC, et al. Among authors: laezza f. FASEB J. 2016 Jun;30(6):2171-86. doi: 10.1096/fj.201500161. Epub 2016 Feb 25. FASEB J. 2016. PMID: 26917740 Free PMC article.
These results suggest that a CK2-FGF14 axis may regulate Nav channels and neuronal excitability.-Hsu, W.-C. J., Scala, F., Nenov, M. N., Wildburger, N. C., Elferink, H., Singh, A. K., Chesson, C. B., Buzhdygan, T., Sohail, M., Shavkunov, A. ...I., Nilsson, C. L., Rudra, J. …
These results suggest that a CK2-FGF14 axis may regulate Nav channels and neuronal excitability.-Hsu, W.-C. J., Scala, F., Nenov, M. …
Consequences of acute Nav1.1 exposure to deltamethrin.
James TF, Nenov MN, Tapia CM, Lecchi M, Koshy S, Green TA, Laezza F. James TF, et al. Among authors: laezza f. Neurotoxicology. 2017 May;60:150-160. doi: 10.1016/j.neuro.2016.12.005. Epub 2016 Dec 19. Neurotoxicology. 2017. PMID: 28007400 Free PMC article.
Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway.
Scala F, Nenov MN, Crofton EJ, Singh AK, Folorunso O, Zhang Y, Chesson BC, Wildburger NC, James TF, Alshammari MA, Alshammari TK, Elfrink H, Grassi C, Kasper JM, Smith AE, Hommel JD, Lichti CF, Rudra JS, D'Ascenzo M, Green TA, Laezza F. Scala F, et al. Among authors: laezza f. Cell Rep. 2018 Apr 10;23(2):555-567. doi: 10.1016/j.celrep.2018.03.062. Cell Rep. 2018. PMID: 29642012 Free PMC article.
80 results