Giaime E - Search Results

1

Discovery of NV-5138, the first selective Brain mTORC1 activator.

Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E. Sengupta S, et al. Among authors: giaime e. Sci Rep. 2019 Mar 11;9(1):4107. doi: 10.1038/s41598-019-40693-5. Sci Rep. 2019. PMID: 30858438 Free PMC article.

2

Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy.

St-Cyr S, Child DD, Giaime E, Smith AR, Pascua CJ, Hahm S, Saiah E, Davidson BL. St-Cyr S, et al. Among authors: giaime e. PLoS One. 2022 Aug 29;17(8):e0273710. doi: 10.1371/journal.pone.0273710. eCollection 2022. PLoS One. 2022. PMID: 36037192 Free PMC article.

3

Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening.

Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J. Giaime E, et al. PLoS One. 2012;7(7):e40501. doi: 10.1371/journal.pone.0040501. Epub 2012 Jul 9. PLoS One. 2012. PMID: 22792356 Free PMC article.

4

Regulation of mitochondrial permeability transition pore by PINK1.

Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J. Gautier CA, et al. Among authors: giaime e. Mol Neurodegener. 2012 May 25;7:22. doi: 10.1186/1750-1326-7-22. Mol Neurodegener. 2012. PMID: 22630785 Free PMC article.

5

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.

Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J. Tong Y, et al. Among authors: giaime e. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9879-84. doi: 10.1073/pnas.1004676107. Epub 2010 May 10. Proc Natl Acad Sci U S A. 2010. PMID: 20457918 Free PMC article.

6

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.

Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Tong Y, et al. Among authors: giaime e. Mol Neurodegener. 2012 Jan 9;7:2. doi: 10.1186/1750-1326-7-2. Mol Neurodegener. 2012. PMID: 22230652 Free PMC article.

7

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

Giaime E, Tong Y, Wagner LK, Yuan Y, Huang G, Shen J. Giaime E, et al. Neuron. 2017 Nov 15;96(4):796-807.e6. doi: 10.1016/j.neuron.2017.09.036. Epub 2017 Oct 19. Neuron. 2017. PMID: 29056298 Free PMC article.

8

A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics.

Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, Shen J, Shen J, Zhou Z, Liu X. Zhang C, et al. Among authors: giaime e. Cell Res. 2015 Mar;25(3):394-7. doi: 10.1038/cr.2014.159. Epub 2014 Dec 5. Cell Res. 2015. PMID: 25475060 Free PMC article. No abstract available.

9

PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions.

Zhang C, Lee S, Peng Y, Bunker E, Giaime E, Shen J, Zhou Z, Liu X. Zhang C, et al. Among authors: giaime e. Curr Biol. 2014 Aug 18;24(16):1854-65. doi: 10.1016/j.cub.2014.07.014. Epub 2014 Jul 31. Curr Biol. 2014. PMID: 25088558 Free PMC article.

10

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z. Lee SB, et al. Among authors: giaime e. Mol Cell. 2015 Oct 1;60(1):21-34. doi: 10.1016/j.molcel.2015.08.011. Epub 2015 Sep 17. Mol Cell. 2015. PMID: 26387737 Free PMC article.

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