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23 results

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Reduced signal for polygenic adaptation of height in UK Biobank.
Berg JJ, Harpak A, Sinnott-Armstrong N, Joergensen AM, Mostafavi H, Field Y, Boyle EA, Zhang X, Racimo F, Pritchard JK, Coop G. Berg JJ, et al. Among authors: harpak a. Elife. 2019 Mar 21;8:e39725. doi: 10.7554/eLife.39725. Elife. 2019. PMID: 30895923 Free PMC article.
Evidence for Weak Selective Constraint on Human Gene Expression.
Glassberg EC, Gao Z, Harpak A, Lan X, Pritchard JK. Glassberg EC, et al. Among authors: harpak a. Genetics. 2019 Feb;211(2):757-772. doi: 10.1534/genetics.118.301833. Epub 2018 Dec 15. Genetics. 2019. PMID: 30554168 Free PMC article.
Variable prediction accuracy of polygenic scores within an ancestry group.
Mostafavi H, Harpak A, Agarwal I, Conley D, Pritchard JK, Przeworski M. Mostafavi H, et al. Among authors: harpak a. Elife. 2020 Jan 30;9:e48376. doi: 10.7554/eLife.48376. Elife. 2020. PMID: 31999256 Free PMC article.
But there is a catch: polygenic scores make less accurate predictions for individuals of a different ancestry than those involved in the GWAS, which limits the use of these tools around the world. ...Using data from the UK Biobank, an international health resource t …
But there is a catch: polygenic scores make less accurate predictions for individuals of a different ancestry than those invol …
Genetic Adaptation in New York City Rats.
Harpak A, Garud N, Rosenberg NA, Petrov DA, Combs M, Pennings PS, Munshi-South J. Harpak A, et al. Genome Biol Evol. 2021 Jan 7;13(1):evaa247. doi: 10.1093/gbe/evaa247. Genome Biol Evol. 2021. PMID: 33211096 Free PMC article.
23 results